Test 1 Report


Sample Level



TEST_IOP
Metric Cells Value Median Counts per Cell Median Genes per Cell 740.0 2195.5 957.0 0 200 400 600 800 0 20 40 Proportion of reads in mitochondrial genes Cells Mitochondrial 0 100 200 300 0 10 20 30 40 Proportion of reads in ribosomal genes Cells Ribosomal 0 50 100 150 0.0 0.2 0.4 Doublet Score Cells Doublet Scores -10 -5 0 5 10 -15 -10 -5 0 5 10 UMAP 1 UMAP 2 10000 20000 30000 40000 UMI Counts -10 -5 0 5 10 -15 -10 -5 0 5 10 UMAP 1 UMAP 2 0.05 0.10 0.15 0.20 Doublet Score -10 -5 0 5 10 -15 -10 -5 0 5 10 UMAP 1 UMAP 2 G1 G2M S Cell Cycle Phase -10 -5 0 5 10 -15 -10 -5 0 5 10 UMAP 1 UMAP 2 0 5 10 15 20 Mito Percentage
TEST_ION
Metric Cells Value Median Counts per Cell Median Genes per Cell 334.0 3172.5 1395.0 0 250 500 750 1000 0 20 40 60 Proportion of reads in mitochondrial genes Cells Mitochondrial 0 100 200 300 0 20 40 60 Proportion of reads in ribosomal genes Cells Ribosomal 0 20 40 60 80 0.0 0.2 0.4 0.6 Doublet Score Cells Doublet Scores -4 0 4 -3 0 3 6 UMAP 1 UMAP 2 10000 20000 30000 UMI Counts -4 0 4 -3 0 3 6 UMAP 1 UMAP 2 0.05 0.10 0.15 0.20 Doublet Score -4 0 4 -3 0 3 6 UMAP 1 UMAP 2 G1 G2M S Cell Cycle Phase -4 0 4 -3 0 3 6 UMAP 1 UMAP 2 5 10 15 20 Mito Percentage
TEST_ASN
Metric Cells Value Median Counts per Cell Median Genes per Cell 1211 8026 2387 0 200 400 600 0 20 40 60 80 Proportion of reads in mitochondrial genes Cells Mitochondrial 0 100 200 0 20 40 60 Proportion of reads in ribosomal genes Cells Ribosomal 0 50 100 150 0.0 0.1 0.2 0.3 0.4 Doublet Score Cells Doublet Scores -6 -3 0 3 -4 -2 0 2 4 UMAP 1 UMAP 2 30000 60000 90000 UMI Counts -6 -3 0 3 -4 -2 0 2 4 UMAP 1 UMAP 2 0.05 0.10 0.15 0.20 Doublet Score -6 -3 0 3 -4 -2 0 2 4 UMAP 1 UMAP 2 G1 G2M S Cell Cycle Phase -6 -3 0 3 -4 -2 0 2 4 UMAP 1 UMAP 2 0 5 10 15 20 Mito Percentage
TEST_RAP
Metric Cells Value Median Counts per Cell Median Genes per Cell 2341 2210 1048 0 1000 2000 0 20 40 60 Proportion of reads in mitochondrial genes Cells Mitochondrial 0 200 400 600 0 20 40 Proportion of reads in ribosomal genes Cells Ribosomal 0 100 200 300 400 500 0.0 0.1 0.2 0.3 0.4 0.5 Doublet Score Cells Doublet Scores -5 0 5 10 15 -15 -10 -5 0 5 UMAP 1 UMAP 2 25000 50000 75000 100000 UMI Counts -5 0 5 10 15 -15 -10 -5 0 5 UMAP 1 UMAP 2 0.05 0.10 0.15 0.20 Doublet Score -5 0 5 10 15 -15 -10 -5 0 5 UMAP 1 UMAP 2 G1 G2M S Cell Cycle Phase -5 0 5 10 15 -15 -10 -5 0 5 UMAP 1 UMAP 2 0 5 10 15 20 Mito Percentage

Batch Level



PATIENT1

-10 -5 0 5 10 15 -10 -5 0 5 10 UMAP-1 UMAP-2 Plasma.cell Monocyte T.cell Dendritic.cell B.cell Mast.cell Endothelial.cell Fibroblast Ovarian.cancer.cell Cell Type -10 -5 0 5 10 15 -10 -5 0 5 10 UMAP-1 UMAP-2 TEST_IOP TEST_ION Sample 0.00 0.25 0.50 0.75 1.00 TEST_ION TEST_IOP Sample Cell Type B.cell Dendritic.cell Endothelial.cell Fibroblast Mast.cell Monocyte Ovarian.cancer.cell Plasma.cell T.cell Composition -10 -5 0 5 10 15 -10 -5 0 5 10 UMAP-1 UMAP-2 0 1 2 3 4 5 6 7 Cluster Plasma.cell Monocyte T.cell Dendritic.cell B.cell Mast.cell Endothelial.cell Fibroblast Ovarian.cancer.cell KRT17 CDH5 MSLN FOLR1 WT1 CLDN4 EMCN EPCAM COL6A2 COL6A1 FBLN1 LGALS1 XBP1 IGLC3 IGLC2 CLDN5 LILRA4 NKG7 CD33 FTL APOC1 APOE CD79A TYROBP PLVAP INSR C3 WFDC2 TCF4 PECAM1 COL1A1 RAMP2 KRT19 CCL4 CCL5 CD68 IRF8 MMP2 ITGAX ITGAM CD19 IL32 TPSAB1 TPSB2 IGHM IGHG3 IGHG1 IGHG2 IGHG4 PLD4 CLEC14A GZMB CTSG TRAC COL4A2 COL4A1 GPR183 POSTN DCN LUM LYZ KRT18 KRT8 KRT7 MGP A2M CLEC4C CD163 C1R C1S CD4 VWF ACTA2 PSAP PRF1 MRC1 MCAM CD3G CD3D CD3E TAGLN NNMT MS4A1 MS4A2 MPEG1 IRF7 CLIC3 PTGDS EGFL7 COL5A1 ENG COL15A1 CTHRC1 CTSB VSIG4 TIMP1 IL3RA RARRES2 CALD1 CAV1 COL1A2 GNG11 CLDN3 AEBP1 AQP1 TSPAN13 CD24 AIF1 SPARC CD74 CD14 MZB1 TCF7 GZMA HPGD BANK1 HPGDS SPP1 SPARCL1 PLAC8 JCHAIN IGFBP7 KIT CCDC50 CPA3 GATA2 CCDC80 COL6A3 IGFBP5 FN1 COL5A2 COL3A1 IGKC CD8A BCL11A PTPRC FCGR3A FCER1G MUC1 S100A9 CTSS CD2 CD52 C1QB C1QC C1QA HSPG2 Features Identity 0 1 2 Average Expression Percent Expressed 0 25 50 75 100 Cell Type Markers
Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 5.670066e-138 2.207703 0.729 0.027 1.110539e-133 0 CYBB
1 2.936062e-118 2.843591 0.936 0.289 5.750571e-114 0 HLA-DRA
2 7.048879e-115 1.890480 0.562 0.002 1.380593e-110 0 MS4A7
3 2.170272e-109 2.009310 0.562 0.009 4.250695e-105 0 MS4A6A
4 3.267343e-109 3.007643 0.602 0.023 6.399417e-105 0 LYZ
5 1.953246e-108 2.473979 0.908 0.278 3.825627e-104 0 HLA-DPA1
6 7.226368e-102 2.329080 0.869 0.253 1.415356e-97 0 HLA-DPB1
7 1.182166e-101 2.209656 0.988 0.632 2.315390e-97 0 CD74
8 5.353019e-100 2.165128 0.574 0.028 1.048442e-95 0 CD14
9 1.389509e-94 1.931600 0.733 0.119 2.721493e-90 0 HLA-DQB1
10 4.296001e-93 2.647933 0.578 0.040 8.414147e-89 0 AC020656.1
11 1.154351e-88 2.159628 0.813 0.258 2.260913e-84 0 CTSS
12 4.178685e-86 2.695707 0.478 0.016 8.184373e-82 0 C1QA
13 9.599777e-82 2.440914 0.466 0.018 1.880212e-77 0 C1QB
14 3.160334e-80 1.914229 0.884 0.327 6.189831e-76 0 HLA-DRB1
15 2.277095e-70 1.907202 0.390 0.010 4.459918e-66 0 MRC1
16 5.475216e-59 1.850670 0.705 0.255 1.072376e-54 0 CTSB
17 2.586757e-52 1.971863 0.343 0.022 5.066423e-48 0 S100A9
18 3.245326e-46 1.845024 0.936 0.786 6.356296e-42 0 FTL
19 1.342784e-36 1.991620 0.343 0.057 2.629976e-32 0 LGMN
20 7.923811e-189 1.892086 0.942 0.027 1.551958e-184 1 DERL3
21 4.486052e-185 2.785775 1.000 0.068 8.786382e-181 1 MZB1
22 7.904436e-183 3.571697 0.966 0.053 1.548163e-178 1 IGHG2
23 1.248054e-167 2.735808 0.952 0.067 2.444438e-163 1 JCHAIN
24 5.830567e-167 3.352462 0.966 0.099 1.141975e-162 1 IGHG3
25 2.601095e-155 1.661071 0.874 0.037 5.094504e-151 1 IGHG4
26 1.585712e-148 2.547784 0.918 0.075 3.105775e-144 1 IGHGP
27 4.859669e-139 4.292590 0.986 0.217 9.518148e-135 1 IGHG1
28 7.804804e-131 1.154039 0.807 0.046 1.528649e-126 1 CD38
29 2.116581e-130 1.483045 0.961 0.137 4.145535e-126 1 FKBP11
30 8.590620e-123 2.082749 1.000 0.301 1.682559e-118 1 XBP1
31 4.695407e-118 1.520894 0.947 0.153 9.196425e-114 1 SEC11C
32 1.280055e-113 2.016057 1.000 0.505 2.507115e-109 1 SSR4
33 4.114560e-93 4.392083 1.000 0.631 8.058778e-89 1 IGKC
34 1.340750e-72 2.120686 0.396 0.010 2.625993e-68 1 IGHV5-51
35 9.575815e-66 2.455202 0.415 0.024 1.875519e-61 1 IGKV1-5
36 1.342523e-65 2.226397 0.415 0.024 2.629465e-61 1 IGHV3-23
37 4.482196e-23 3.216830 0.314 0.061 8.778829e-19 1 IGHA1
38 7.839441e-19 4.086893 0.604 0.219 1.535433e-14 1 IGLC2
39 1.713624e-11 5.051128 0.377 0.145 3.356303e-07 1 IGLC3
40 8.374319e-55 1.715922 0.659 0.142 1.640194e-50 2 CCL5
41 1.698079e-47 1.552282 0.506 0.081 3.325858e-43 2 NKG7
42 3.806963e-46 1.414668 0.524 0.093 7.456317e-42 2 GZMA
43 5.596048e-42 1.233548 0.652 0.175 1.096042e-37 2 CD2
44 2.351333e-41 1.359319 0.409 0.058 4.605321e-37 2 CST7
45 4.850941e-39 1.159046 0.530 0.112 9.501054e-35 2 CD3G
46 1.788665e-36 1.333548 0.652 0.224 3.503278e-32 2 IL32
47 7.712082e-34 1.947789 0.488 0.124 1.510488e-29 2 CCL4
48 2.187587e-33 1.368103 0.421 0.087 4.284609e-29 2 CD69
49 2.567562e-33 1.228465 0.482 0.112 5.028827e-29 2 CD3D
50 2.219153e-29 1.048923 0.311 0.046 4.346433e-25 2 GZMM
51 7.547913e-29 1.262055 0.610 0.256 1.478334e-24 2 CXCR4
52 6.455158e-28 1.237599 0.280 0.038 1.264307e-23 2 PRF1
53 2.127112e-26 1.066496 0.415 0.104 4.166162e-22 2 RUNX3
54 4.592036e-26 1.050039 0.805 0.554 8.993961e-22 2 BTG1
55 5.329644e-24 1.036127 0.268 0.042 1.043864e-19 2 KLRB1
56 7.982864e-23 1.052769 0.445 0.148 1.563524e-18 2 SLA
57 2.810275e-21 1.230019 0.341 0.091 5.504204e-17 2 DUSP2
58 1.760224e-20 1.207476 0.341 0.088 3.447575e-16 2 IL7R
59 1.094122e-17 1.196895 0.445 0.189 2.142948e-13 2 TNFAIP3
60 2.154325e-201 3.585888 0.944 0.016 4.219460e-197 3 VWF
61 2.769034e-179 2.251541 0.815 0.004 5.423430e-175 3 CLEC14A
62 2.105197e-177 2.546758 0.907 0.032 4.123238e-173 3 EGFL7
63 6.471517e-172 2.140644 0.784 0.004 1.267511e-167 3 ADGRL4
64 2.473609e-171 2.793137 0.809 0.011 4.844811e-167 3 AQP1
65 1.719780e-155 2.964170 0.957 0.088 3.368361e-151 3 HSPG2
66 2.482008e-154 2.267796 0.846 0.038 4.861261e-150 3 CD34
67 1.596066e-146 2.202976 0.698 0.008 3.126055e-142 3 PLVAP
68 2.858725e-145 2.518217 0.722 0.014 5.599098e-141 3 COL15A1
69 3.979197e-135 2.143736 0.710 0.022 7.793655e-131 3 RAMP2
70 1.789234e-127 2.637148 0.858 0.075 3.504394e-123 3 COL4A1
71 4.671273e-126 2.505904 0.870 0.100 9.149154e-122 3 ENG
72 2.731362e-117 2.301943 0.790 0.064 5.349646e-113 3 COL4A2
73 1.645686e-114 2.367567 0.957 0.211 3.223241e-110 3 PECAM1
74 1.469276e-113 2.286474 0.556 0.007 2.877723e-109 3 CLDN5
75 1.249906e-106 2.120304 0.944 0.146 2.448065e-102 3 SPARCL1
76 5.310298e-103 2.487907 0.932 0.191 1.040075e-98 3 A2M
77 1.952911e-98 2.545751 0.506 0.010 3.824972e-94 3 ACKR1
78 1.181307e-87 2.834508 0.580 0.038 2.313708e-83 3 FABP4
79 3.223194e-64 2.131130 0.784 0.243 6.312948e-60 3 CAV1
80 1.094059e-67 1.800637 0.856 0.173 2.142823e-63 4 CD2
81 8.496815e-46 1.198489 1.000 0.893 1.664186e-41 4 RPS29
82 8.571088e-46 1.515939 0.805 0.246 1.678733e-41 4 CD52
83 1.891143e-40 1.476765 0.593 0.124 3.703992e-36 4 CD3G
84 7.780705e-40 1.606716 0.746 0.233 1.523929e-35 4 IL32
85 1.348503e-29 1.297763 0.517 0.126 2.641179e-25 4 CD3D
86 1.494691e-29 1.404355 0.492 0.115 2.927501e-25 4 TRBC2
87 3.401929e-28 1.119151 0.458 0.098 6.663017e-24 4 CD3E
88 1.025288e-27 1.284244 0.492 0.122 2.008129e-23 4 TRAC
89 4.303011e-27 1.252433 0.305 0.042 8.427878e-23 4 CD247
90 2.386799e-26 1.486011 0.441 0.103 4.674785e-22 4 TRBC1
91 1.438726e-21 1.115315 0.610 0.258 2.817888e-17 4 CORO1A
92 2.487936e-21 1.419948 0.390 0.094 4.872871e-17 4 IL7R
93 8.291964e-21 1.293300 0.441 0.124 1.624064e-16 4 GZMA
94 3.625604e-20 1.504119 0.517 0.184 7.101108e-16 4 CCL5
95 2.688015e-19 1.183367 0.297 0.060 5.264745e-15 4 SAMD3
96 1.446760e-17 1.093883 0.542 0.246 2.833623e-13 4 IKZF1
97 3.737001e-17 1.099781 0.483 0.169 7.319289e-13 4 LTB
98 2.795698e-13 1.256962 0.356 0.120 5.475654e-09 4 NKG7
99 1.144011e-10 1.514669 0.712 0.613 2.240661e-06 4 PLCG2
100 3.743942e-203 3.897669 0.980 0.014 7.332886e-199 5 DCN
101 4.999192e-192 3.055214 0.940 0.014 9.791418e-188 5 FBLN1
102 2.447895e-181 3.870733 0.970 0.028 4.794447e-177 5 CCDC80
103 7.076633e-175 3.295593 0.900 0.020 1.386029e-170 5 LUM
104 1.154054e-153 2.182135 0.870 0.029 2.260330e-149 5 RARRES2
105 3.730178e-153 2.644566 0.910 0.035 7.305928e-149 5 COL6A3
106 5.372347e-152 2.199895 0.920 0.039 1.052228e-147 5 C1S
107 5.484006e-150 2.948008 0.990 0.062 1.074097e-145 5 COL6A1
108 2.650763e-141 4.447321 1.000 0.080 5.191785e-137 5 COL3A1
109 3.359513e-140 4.470877 1.000 0.083 6.579942e-136 5 COL1A2
110 3.219842e-133 4.630486 1.000 0.094 6.306383e-129 5 COL1A1
111 1.341655e-132 2.319500 0.940 0.067 2.627766e-128 5 MMP2
112 2.662249e-131 2.228258 0.860 0.047 5.214282e-127 5 SERPINF1
113 3.421410e-125 2.768697 1.000 0.103 6.701174e-121 5 COL6A2
114 1.236855e-124 2.896351 0.580 0.003 2.422504e-120 5 SFRP2
115 8.297711e-121 2.231892 0.860 0.056 1.625190e-116 5 C1R
116 6.977127e-120 2.842561 0.870 0.060 1.366540e-115 5 C3
117 9.631335e-95 2.960779 0.550 0.016 1.886393e-90 5 C7
118 3.891156e-93 2.501552 0.880 0.109 7.621218e-89 5 MGP
119 7.124643e-90 2.464704 0.400 0.000 1.395433e-85 5 SFRP4
120 1.626666e-185 1.946873 0.837 0.002 3.185988e-181 6 S100A1
121 2.596331e-174 2.025937 0.791 0.002 5.085175e-170 6 SLC34A2
122 9.244625e-174 3.018178 0.860 0.006 1.810652e-169 6 WFDC2
123 2.044720e-173 2.432785 0.907 0.009 4.004788e-169 6 C19orf33
124 4.313588e-170 2.285070 0.884 0.008 8.448593e-166 6 MUC16
125 2.101514e-165 2.177058 0.791 0.004 4.116025e-161 6 EPCAM
126 7.407932e-158 2.511938 0.884 0.012 1.450918e-153 6 SLPI
127 3.583323e-144 1.875876 0.721 0.005 7.018297e-140 6 MT1G
128 2.156598e-143 1.934885 0.698 0.004 4.223912e-139 6 ELF3
129 1.302241e-139 2.115636 0.791 0.011 2.550569e-135 6 MSLN
130 5.498835e-130 1.751750 0.721 0.009 1.077002e-125 6 CP
131 2.058410e-120 2.348165 0.884 0.026 4.031603e-116 6 CD24
132 1.320323e-119 2.407645 0.558 0.002 2.585984e-115 6 MMP7
133 5.719136e-115 2.491437 0.884 0.031 1.120150e-110 6 CDKN2A
134 2.090291e-76 1.757802 0.837 0.054 4.094043e-72 6 RBP1
135 2.352068e-71 2.042908 0.884 0.074 4.606761e-67 6 SPINT2
136 1.141395e-67 2.159576 0.698 0.039 2.235537e-63 6 GPX3
137 1.051453e-45 1.809198 0.884 0.127 2.059376e-41 6 BCAM
138 5.564578e-42 2.264224 0.977 0.180 1.089878e-37 6 CLU
139 1.734378e-20 2.400303 0.977 0.832 3.396952e-16 6 FTH1
140 1.524147e-110 2.545557 0.793 0.015 2.985195e-106 7 RGS5
141 1.076619e-104 2.051807 0.690 0.011 2.108666e-100 7 NDUFA4L2
142 6.822749e-103 2.636515 0.828 0.021 1.336304e-98 7 CARMN
143 4.244684e-94 2.209402 0.759 0.019 8.313638e-90 7 NOTCH3
144 8.104119e-84 2.140358 0.897 0.038 1.587273e-79 7 PLAC9
145 5.326157e-72 3.562863 0.931 0.056 1.043181e-67 7 ACTA2
146 5.638235e-67 2.114153 0.724 0.032 1.104305e-62 7 PDGFA
147 4.710122e-61 2.454251 0.897 0.064 9.225245e-57 7 PDGFRB
148 4.168592e-60 2.543449 0.517 0.014 8.164603e-56 7 MYH11
149 3.827086e-47 3.594864 0.897 0.096 7.495731e-43 7 TAGLN
150 1.490459e-39 1.970872 0.793 0.080 2.919213e-35 7 MAP1B
151 2.210194e-39 2.618499 0.828 0.100 4.328885e-35 7 TPM2
152 2.511272e-39 2.542450 0.828 0.100 4.918578e-35 7 MYL9
153 2.278355e-29 2.589331 1.000 0.237 4.462386e-25 7 CALD1
154 3.639056e-29 1.940016 0.931 0.188 7.127454e-25 7 COL18A1
155 2.665398e-28 1.978748 0.759 0.115 5.220448e-24 7 PMEPA1
156 1.387894e-27 2.359281 0.931 0.213 2.718329e-23 7 TPM1
157 1.536115e-23 2.093403 0.448 0.041 3.008636e-19 7 IGFBP5
158 8.361530e-22 2.004117 0.966 0.287 1.637689e-17 7 IGFBP7
159 6.850854e-20 2.054510 0.690 0.130 1.341808e-15 7 ADIRF
PATIENT2

-10 0 10 -5 0 5 10 UMAP-1 UMAP-2 Ovarian.cancer.cell Fibroblast Monocyte T.cell Mast.cell Plasma.cell B.cell Dendritic.cell Endothelial.cell Cell Type -10 0 10 -5 0 5 10 UMAP-1 UMAP-2 TEST_ASN TEST_RAP Sample 0.00 0.25 0.50 0.75 1.00 TEST_ASN TEST_RAP Sample Cell Type B.cell Dendritic.cell Endothelial.cell Fibroblast Mast.cell Monocyte Ovarian.cancer.cell Plasma.cell T.cell Composition -10 0 10 -5 0 5 10 UMAP-1 UMAP-2 0 1 2 3 4 5 6 Cluster Ovarian.cancer.cell Fibroblast Monocyte T.cell Mast.cell Plasma.cell B.cell Dendritic.cell Endothelial.cell IGLC3 IGLC2 LILRA4 CDH5 TPSAB1 TPSB2 IGHG2 IGHG4 GZMB CLEC4C PRF1 CD3G CD3E MS4A1 MS4A2 MPEG1 GZMA EMCN HPGDS KIT CPA3 COL6A2 COL6A1 FBLN1 LGALS1 XBP1 CLDN5 NKG7 CD33 FTL APOC1 APOE CD79A TYROBP PLVAP INSR C3 WFDC2 TCF4 PECAM1 COL1A1 RAMP2 KRT17 KRT19 CCL4 CCL5 CD68 IRF8 MMP2 ITGAX ITGAM CD19 IL32 MSLN IGHM IGHG3 IGHG1 PLD4 CTSG TRAC COL4A2 COL4A1 GPR183 POSTN DCN LUM LYZ KRT18 KRT8 KRT7 MGP A2M CD163 C1R C1S CD4 VWF ACTA2 PSAP MRC1 MCAM CD3D TAGLN NNMT FOLR1 WT1 IRF7 CLIC3 PTGDS EGFL7 COL5A1 ENG COL15A1 CTHRC1 CTSB VSIG4 TIMP1 IL3RA RARRES2 CALD1 CAV1 COL1A2 GNG11 CLDN4 CLDN3 AEBP1 AQP1 TSPAN13 CD24 AIF1 SPARC CD74 CD14 MZB1 TCF7 HPGD BANK1 SPP1 SPARCL1 PLAC8 JCHAIN IGFBP7 CCDC50 GATA2 CCDC80 COL6A3 IGFBP5 FN1 COL5A2 COL3A1 IGKC CD8A BCL11A EPCAM PTPRC FCGR3A FCER1G MUC1 S100A9 CTSS CD2 CD52 C1QB C1QC C1QA HSPG2 Features Identity 0 1 2 Average Expression Percent Expressed 0 25 50 75 100 Cell Type Markers
Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 0.000000e+00 2.291196 0.738 0.087 0.000000e+00 0 IL7R
1 0.000000e+00 2.035523 0.882 0.114 0.000000e+00 0 CD2
2 0.000000e+00 1.675889 0.990 0.603 0.000000e+00 0 BTG1
3 0.000000e+00 1.660168 0.762 0.089 0.000000e+00 0 CD3D
4 0.000000e+00 1.645897 0.949 0.515 0.000000e+00 0 TXNIP
5 0.000000e+00 1.592565 0.695 0.072 0.000000e+00 0 CD3G
6 0.000000e+00 1.452289 0.920 0.301 0.000000e+00 0 PTPRC
7 1.363330e-303 1.464128 0.915 0.423 2.897077e-299 0 CXCR4
8 1.495926e-299 1.475488 0.777 0.172 3.178844e-295 0 ETS1
9 5.701812e-285 1.570222 0.631 0.073 1.211635e-280 0 TRAC
10 3.592940e-277 1.462713 0.632 0.081 7.634998e-273 0 CD3E
11 7.649601e-257 1.459407 0.726 0.176 1.625540e-252 0 SLA
12 9.391360e-224 1.674157 0.549 0.077 1.995664e-219 0 TRBC1
13 1.008076e-209 1.462170 0.543 0.090 2.142161e-205 0 GIMAP7
14 1.168091e-198 1.406011 0.518 0.077 2.482193e-194 0 TRBC2
15 1.710295e-195 1.375436 0.587 0.149 3.634376e-191 0 FYN
16 3.509745e-195 1.377083 0.657 0.244 7.458207e-191 0 LEPROTL1
17 2.928562e-193 1.415161 0.722 0.314 6.223194e-189 0 IL32
18 3.225515e-191 1.752027 0.446 0.046 6.854220e-187 0 GZMK
19 8.924439e-129 1.416923 0.359 0.053 1.896443e-124 0 CD8A
20 0.000000e+00 2.039420 0.888 0.129 0.000000e+00 1 SOX4
21 0.000000e+00 1.974646 0.894 0.121 0.000000e+00 1 CLDN3
22 0.000000e+00 1.970159 0.762 0.069 0.000000e+00 1 AKAP12
23 0.000000e+00 1.857724 0.752 0.048 0.000000e+00 1 MUC4
24 0.000000e+00 1.821210 0.829 0.049 0.000000e+00 1 CLDN4
25 0.000000e+00 1.667522 0.729 0.061 0.000000e+00 1 ELF3
26 0.000000e+00 1.587733 0.762 0.073 0.000000e+00 1 TACSTD2
27 0.000000e+00 1.580437 0.756 0.060 0.000000e+00 1 ITGB8
28 0.000000e+00 1.566079 0.904 0.171 0.000000e+00 1 CD24
29 0.000000e+00 1.558405 0.758 0.088 0.000000e+00 1 IGFBP3
30 0.000000e+00 1.514290 0.818 0.089 0.000000e+00 1 PAX8
31 0.000000e+00 1.503988 0.861 0.143 0.000000e+00 1 KRT19
32 0.000000e+00 1.447859 0.902 0.165 0.000000e+00 1 KRT18
33 0.000000e+00 1.419625 0.854 0.103 0.000000e+00 1 AFDN
34 0.000000e+00 1.394568 0.861 0.151 0.000000e+00 1 EPCAM
35 0.000000e+00 1.372322 0.813 0.096 0.000000e+00 1 PPFIBP1
36 1.311327e-252 1.405370 0.606 0.067 2.786569e-248 1 ID1
37 7.075589e-212 1.385157 0.618 0.094 1.503563e-207 1 KRT17
38 2.488752e-138 3.197954 0.794 0.272 5.288598e-134 1 PLCG2
39 7.651999e-96 1.971043 0.323 0.056 1.626050e-91 1 MT1G
40 0.000000e+00 5.596133 0.954 0.098 0.000000e+00 2 IGHG1
41 0.000000e+00 4.126280 0.956 0.040 0.000000e+00 2 IGHG3
42 0.000000e+00 3.904322 0.960 0.017 0.000000e+00 2 JCHAIN
43 0.000000e+00 3.274866 0.917 0.009 0.000000e+00 2 IGHG2
44 0.000000e+00 2.551312 0.988 0.051 0.000000e+00 2 MZB1
45 0.000000e+00 2.235920 0.998 0.233 0.000000e+00 2 XBP1
46 0.000000e+00 1.836773 0.887 0.007 0.000000e+00 2 IGHG4
47 0.000000e+00 1.566813 0.843 0.007 0.000000e+00 2 IGHGP
48 0.000000e+00 1.446756 0.895 0.015 0.000000e+00 2 DERL3
49 1.094626e-298 2.400628 0.450 0.005 2.326079e-294 2 IGHV1-24
50 1.052285e-295 1.246338 0.970 0.229 2.236107e-291 2 PRDX4
51 2.436916e-280 1.946948 1.000 0.623 5.178446e-276 2 SSR4
52 1.724792e-276 2.913265 0.431 0.007 3.665182e-272 2 IGKV3-11
53 6.805687e-257 1.294985 0.984 0.309 1.446209e-252 2 SEC11C
54 2.099890e-236 3.390110 0.419 0.012 4.462266e-232 2 IGHA1
55 2.088968e-227 1.367453 0.365 0.006 4.439056e-223 2 DNAAF1
56 7.504585e-180 6.279264 0.964 0.416 1.594724e-175 2 IGKC
57 4.535378e-169 2.544241 0.389 0.028 9.637678e-165 2 IGHM
58 2.770768e-161 5.697852 0.609 0.097 5.887882e-157 2 IGLC2
59 1.208947e-118 6.178220 0.742 0.221 2.569013e-114 2 IGLC3
60 7.298232e-233 1.437336 0.869 0.181 1.550874e-228 3 S100A1
61 2.658260e-232 2.012033 0.991 0.243 5.648802e-228 3 WFDC2
62 1.185831e-231 2.043459 1.000 0.831 2.519891e-227 3 GAPDH
63 9.272330e-221 1.960941 0.914 0.198 1.970370e-216 3 MMP7
64 2.263105e-219 1.509018 0.941 0.267 4.809098e-215 3 C12orf75
65 2.314091e-218 1.760626 0.998 0.528 4.917444e-214 3 GSTP1
66 1.141196e-216 1.481053 0.968 0.299 2.425042e-212 3 GLO1
67 7.364387e-212 1.366870 0.957 0.228 1.564932e-207 3 C19orf33
68 8.534509e-210 1.359856 0.950 0.259 1.813583e-205 3 CDKN2A
69 4.865882e-208 1.655471 0.989 0.501 1.034000e-203 3 TPI1
70 8.326354e-208 1.587950 0.971 0.273 1.769350e-203 3 MDK
71 2.813026e-207 1.414915 0.944 0.227 5.977681e-203 3 KRT7
72 9.214294e-206 1.419866 0.928 0.229 1.958038e-201 3 KRT8
73 2.944954e-202 1.390700 1.000 0.936 6.258028e-198 3 RPS19
74 7.213992e-198 1.415591 0.982 0.498 1.532973e-193 3 ROMO1
75 8.315779e-186 1.834595 0.885 0.212 1.767103e-181 3 SLPI
76 6.171803e-185 1.488627 0.797 0.182 1.311508e-180 3 IGFBP2
77 4.186850e-179 1.433896 0.986 0.550 8.897056e-175 3 ENO1
78 1.096365e-171 1.416206 0.968 0.509 2.329776e-167 3 LDHB
79 1.748422e-146 1.366457 0.560 0.102 3.715396e-142 3 TAGLN
80 0.000000e+00 2.703552 0.532 0.007 0.000000e+00 4 LYZ
81 0.000000e+00 2.297281 0.577 0.008 0.000000e+00 4 AIF1
82 2.018095e-293 2.503494 0.677 0.036 4.288452e-289 4 TYROBP
83 5.138356e-272 1.973261 0.444 0.007 1.091901e-267 4 AC020656.1
84 2.001174e-265 2.184186 0.629 0.034 4.252494e-261 4 FCER1G
85 6.025519e-227 2.281612 0.790 0.094 1.280423e-222 4 HLA-DQA1
86 2.332682e-213 3.131424 0.968 0.229 4.956950e-209 4 HLA-DRA
87 5.205594e-209 2.235561 0.331 0.004 1.106189e-204 4 C1QC
88 4.926378e-202 2.500865 0.367 0.009 1.046855e-197 4 C1QA
89 1.168569e-180 1.865275 0.496 0.036 2.483210e-176 4 FGL2
90 1.950886e-178 2.588874 0.339 0.009 4.145634e-174 4 C1QB
91 5.239297e-162 2.228002 0.323 0.010 1.113351e-157 4 RNASE1
92 1.811461e-150 2.422216 0.919 0.297 3.849354e-146 4 HLA-DRB1
93 1.154250e-147 2.655790 0.980 0.519 2.452782e-143 4 CD74
94 7.404078e-147 1.954665 0.891 0.246 1.573367e-142 4 HLA-DPB1
95 1.134258e-136 2.730097 0.359 0.022 2.410299e-132 4 CXCL10
96 4.678744e-131 2.022052 0.871 0.293 9.942331e-127 4 HLA-DPA1
97 2.690707e-58 1.945668 0.323 0.058 5.717753e-54 4 APOC1
98 2.694217e-36 2.378071 0.302 0.077 5.725211e-32 4 S100A9
99 6.203360e-13 2.470181 0.339 0.199 1.318214e-08 4 APOE
100 0.000000e+00 2.601198 0.772 0.034 0.000000e+00 5 GZMB
101 1.205552e-203 1.686170 0.406 0.010 2.561799e-199 5 KLRC1
102 1.093829e-202 3.387831 0.594 0.036 2.324387e-198 5 GNLY
103 1.451430e-180 1.968773 0.611 0.045 3.084288e-176 5 KLRD1
104 9.593504e-169 1.466149 0.389 0.013 2.038620e-164 5 TRDC
105 2.132469e-165 1.536818 0.594 0.047 4.531496e-161 5 CTSW
106 1.745678e-131 1.291955 0.400 0.024 3.709565e-127 5 HOPX
107 7.382496e-131 1.983661 0.806 0.139 1.568780e-126 5 NKG7
108 3.957218e-119 1.424790 0.472 0.041 8.409088e-115 5 XCL2
109 5.918709e-113 1.394809 0.594 0.074 1.257726e-108 5 PRF1
110 6.804976e-112 1.398928 0.389 0.029 1.446057e-107 5 XCL1
111 6.995738e-95 1.638704 0.383 0.034 1.486594e-90 5 CCL3
112 1.165543e-84 1.755482 0.872 0.286 2.476779e-80 5 CCL5
113 1.085748e-78 1.273696 0.672 0.142 2.307214e-74 5 CD7
114 2.335836e-70 1.449247 0.789 0.212 4.963651e-66 5 CCL4
115 1.234270e-62 1.197188 0.711 0.188 2.622825e-58 5 GZMA
116 5.156028e-54 1.540563 0.322 0.044 1.095656e-49 5 CXCL13
117 1.295539e-42 1.226787 0.472 0.133 2.753019e-38 5 CLIC3
118 2.714764e-33 1.245425 0.556 0.219 5.768873e-29 5 LGALS1
119 2.345447e-21 1.527564 0.467 0.207 4.984075e-17 5 AREG
120 2.403691e-79 1.547266 1.000 0.880 5.107842e-75 6 MT-ATP6
121 7.906462e-74 1.554850 1.000 0.817 1.680123e-69 6 MT-CYB
122 2.127436e-67 1.328970 1.000 0.892 4.520801e-63 6 MT-ND3
123 4.145096e-64 1.326016 1.000 0.863 8.808330e-60 6 MT-CO3
124 4.642133e-64 1.197494 1.000 0.908 9.864532e-60 6 MT-CO1
125 3.327746e-62 1.227177 1.000 0.838 7.071460e-58 6 MT-ND4
126 1.335924e-59 1.116764 1.000 0.895 2.838838e-55 6 MT-CO2
127 2.489187e-59 1.088372 1.000 0.866 5.289522e-55 6 MT-ND1
128 3.005493e-53 0.933402 1.000 0.850 6.386673e-49 6 MT-ND2
129 1.227807e-49 0.957598 0.987 0.727 2.609090e-45 6 MT-ND5
130 1.773051e-32 0.847379 0.866 0.532 3.767733e-28 6 MT-ND4L
131 1.594019e-23 0.903972 0.638 0.275 3.387291e-19 6 CD69
132 1.003941e-20 1.011479 0.268 0.065 2.133375e-16 6 KLRD1
133 4.911974e-18 0.750417 0.638 0.309 1.043794e-13 6 IL7R
134 4.820089e-17 1.224313 0.409 0.163 1.024269e-12 6 NKG7
135 3.270185e-14 0.713880 0.732 0.551 6.949144e-10 6 MTRNR2L12
136 7.138117e-14 1.032587 0.275 0.093 1.516850e-09 6 PRF1
137 1.998701e-08 0.756138 0.463 0.326 4.247240e-04 6 MT-ND6
138 6.158003e-08 0.950137 0.376 0.214 1.308576e-03 6 AREG
139 1.346563e-07 0.933825 0.409 0.234 2.861445e-03 6 CCL4

Project Level


-20 -10 0 10 20 -10 0 10 UMAP-1 UMAP-2 Plasma.cell Monocyte T.cell Dendritic.cell B.cell Mast.cell Endothelial.cell Fibroblast Ovarian.cancer.cell Integrated Cell Type -20 -10 0 10 20 -10 0 10 UMAP-1 UMAP-2 TEST_IOP TEST_ION TEST_ASN TEST_RAP Integrated Sample 0.00 0.25 0.50 0.75 1.00 PATIENT1 PATIENT2 Batch Cell Type B.cell Dendritic.cell Endothelial.cell Fibroblast Mast.cell Monocyte Ovarian.cancer.cell Plasma.cell T.cell Celltypes 0 500 1000 1500 B.cell Dendritic.cell Endothelial.cell Fibroblast Mast.cell Monocyte Ovarian.cancer.cell Plasma.cell T.cell Cells Cell Types
Cell Type Markers



p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 0.000000e+00 2.674690 0.919 0.086 0.000000e+00 Plasma.cell IGHG2
1 0.000000e+00 2.548395 0.965 0.118 0.000000e+00 Plasma.cell IGHG3
2 0.000000e+00 2.428439 0.997 0.122 0.000000e+00 Plasma.cell MZB1
3 0.000000e+00 2.290171 0.869 0.082 0.000000e+00 Plasma.cell IGHGP
4 0.000000e+00 2.010451 0.952 0.096 0.000000e+00 Plasma.cell JCHAIN
5 0.000000e+00 1.645190 0.929 0.080 0.000000e+00 Plasma.cell DERL3
6 0.000000e+00 1.487044 0.846 0.080 0.000000e+00 Plasma.cell IGHG4
7 2.287114e-307 2.436164 0.965 0.185 5.065042e-303 Plasma.cell IGHG1
8 8.843548e-263 1.883890 0.992 0.303 1.958492e-258 Plasma.cell XBP1
9 1.646590e-258 1.026812 0.751 0.095 3.646537e-254 Plasma.cell CD79A
10 3.331018e-243 1.227897 0.952 0.210 7.376874e-239 Plasma.cell FKBP11
11 1.017824e-209 1.908506 0.252 0.003 2.254073e-205 Plasma.cell IGHV3-23
12 3.520622e-205 1.169144 0.940 0.284 7.796770e-201 Plasma.cell PRDX4
13 4.416765e-205 1.634411 0.992 0.627 9.781368e-201 Plasma.cell SSR4
14 2.156589e-193 1.253777 0.952 0.327 4.775982e-189 Plasma.cell SEC11C
15 1.566225e-178 5.830958 0.746 0.146 3.468563e-174 Plasma.cell IGLC2
16 2.585513e-152 0.988317 0.849 0.272 5.725877e-148 Plasma.cell ERLEC1
17 1.737039e-122 3.204599 0.385 0.050 3.846847e-118 Plasma.cell IGHA1
18 2.627164e-92 6.611926 0.645 0.235 5.818117e-88 Plasma.cell IGLC3
19 3.528246e-77 1.737165 0.965 0.501 7.813653e-73 Plasma.cell IGKC
20 0.000000e+00 3.217851 0.790 0.011 0.000000e+00 Monocyte LYZ
21 0.000000e+00 2.949468 0.597 0.010 0.000000e+00 Monocyte C1QA
22 0.000000e+00 2.863574 0.577 0.010 0.000000e+00 Monocyte C1QB
23 0.000000e+00 2.757375 0.710 0.014 0.000000e+00 Monocyte AC020656.1
24 0.000000e+00 2.510432 0.869 0.047 0.000000e+00 Monocyte TYROBP
25 0.000000e+00 2.415753 0.798 0.012 0.000000e+00 Monocyte AIF1
26 0.000000e+00 2.339407 0.506 0.005 0.000000e+00 Monocyte C1QC
27 0.000000e+00 2.318349 0.713 0.013 0.000000e+00 Monocyte CD14
28 0.000000e+00 2.217288 0.730 0.008 0.000000e+00 Monocyte MS4A6A
29 0.000000e+00 2.183000 0.810 0.038 0.000000e+00 Monocyte FCER1G
30 5.796392e-260 2.858141 0.969 0.264 1.283669e-255 Monocyte HLA-DRA
31 7.028957e-216 2.167746 0.935 0.320 1.556633e-211 Monocyte CTSS
32 1.622094e-214 2.548400 0.503 0.045 3.592289e-210 Monocyte RNASE1
33 3.219530e-201 2.233611 0.949 0.430 7.129972e-197 Monocyte PSAP
34 1.269378e-194 2.329129 0.909 0.309 2.811164e-190 Monocyte HLA-DPA1
35 6.533816e-191 2.415659 0.989 0.557 1.446979e-186 Monocyte CD74
36 2.380301e-187 2.269062 0.918 0.322 5.271414e-183 Monocyte HLA-DRB1
37 9.941371e-139 2.471916 0.452 0.064 2.201616e-134 Monocyte S100A9
38 4.018430e-128 2.450037 0.290 0.023 8.899216e-124 Monocyte CXCL10
39 3.424123e-55 2.179858 0.469 0.179 7.583062e-51 Monocyte APOE
40 0.000000e+00 3.108283 0.646 0.037 0.000000e+00 T.cell IL7R
41 0.000000e+00 2.931924 0.666 0.052 0.000000e+00 T.cell CCL5
42 0.000000e+00 2.743100 0.856 0.034 0.000000e+00 T.cell CD2
43 0.000000e+00 2.143100 0.702 0.029 0.000000e+00 T.cell CD3D
44 0.000000e+00 2.113813 0.535 0.020 0.000000e+00 T.cell TRBC1
45 0.000000e+00 2.040164 0.957 0.546 0.000000e+00 T.cell BTG1
46 0.000000e+00 2.036676 0.479 0.021 0.000000e+00 T.cell GZMA
47 0.000000e+00 1.992703 0.652 0.020 0.000000e+00 T.cell CD3G
48 0.000000e+00 1.908265 0.901 0.496 0.000000e+00 T.cell TXNIP
49 0.000000e+00 1.884019 0.859 0.321 0.000000e+00 T.cell CXCR4
50 0.000000e+00 1.866831 0.700 0.240 0.000000e+00 T.cell IL32
51 0.000000e+00 1.865359 0.753 0.120 0.000000e+00 T.cell ETS1
52 0.000000e+00 1.860069 0.587 0.028 0.000000e+00 T.cell TRAC
53 0.000000e+00 1.847532 0.685 0.103 0.000000e+00 T.cell SLA
54 0.000000e+00 1.842504 0.922 0.251 0.000000e+00 T.cell PTPRC
55 0.000000e+00 1.774270 0.512 0.026 0.000000e+00 T.cell TRBC2
56 0.000000e+00 1.750799 0.597 0.019 0.000000e+00 T.cell CD3E
57 5.479184e-263 1.963947 0.393 0.011 1.213420e-258 T.cell GZMK
58 1.314509e-249 2.744678 0.474 0.066 2.911112e-245 T.cell CCL4
59 1.001957e-232 2.001650 0.384 0.025 2.218935e-228 T.cell NKG7
60 0.000000e+00 1.901505 0.786 0.000 0.000000e+00 Dendritic.cell CLEC4C
61 0.000000e+00 1.850846 0.857 0.001 0.000000e+00 Dendritic.cell LILRA4
62 5.967127e-124 2.345081 0.429 0.003 1.321480e-119 Dendritic.cell TCL1A
63 3.233217e-100 2.003845 0.786 0.017 7.160282e-96 Dendritic.cell PLD4
64 2.010410e-91 2.182896 0.857 0.022 4.452255e-87 Dendritic.cell LINC00996
65 1.050792e-69 2.775268 0.929 0.037 2.327084e-65 Dendritic.cell IRF8
66 2.703036e-55 2.262227 0.929 0.046 5.986143e-51 Dendritic.cell MPEG1
67 2.818445e-43 2.696164 1.000 0.070 6.241728e-39 Dendritic.cell GZMB
68 4.043580e-35 1.790552 0.929 0.077 8.954912e-31 Dendritic.cell SLC15A4
69 1.056049e-31 2.407407 0.929 0.088 2.338727e-27 Dendritic.cell IRF4
70 8.762165e-31 2.299084 0.857 0.077 1.940469e-26 Dendritic.cell PLAC8
71 3.843492e-25 1.808360 0.857 0.096 8.511797e-21 Dendritic.cell BCL11A
72 2.589669e-21 2.974599 0.571 0.047 5.735080e-17 Dendritic.cell PTGDS
73 2.732324e-20 2.282397 1.000 0.174 6.051004e-16 Dendritic.cell GPR183
74 8.749452e-20 1.954579 0.786 0.106 1.937654e-15 Dendritic.cell TSPAN13
75 1.695482e-19 2.386989 1.000 0.192 3.754814e-15 Dendritic.cell TCF4
76 8.280955e-14 1.773480 0.857 0.190 1.833900e-09 Dendritic.cell CCDC88A
77 2.693525e-11 1.953094 0.714 0.130 5.965081e-07 Dendritic.cell PRMT9
78 2.061356e-09 1.941855 1.000 0.588 4.565079e-05 Dendritic.cell CD74
79 1.393719e-06 1.832545 0.857 0.462 3.086531e-02 Dendritic.cell TXN
80 0.000000e+00 2.978342 0.428 0.009 0.000000e+00 B.cell IGKV3-11
81 0.000000e+00 2.235885 0.436 0.012 0.000000e+00 B.cell IGHV1-24
82 0.000000e+00 1.322899 0.810 0.078 0.000000e+00 B.cell CD79A
83 9.083494e-278 1.218401 0.698 0.084 2.011631e-273 B.cell IGHG4
84 1.060027e-259 1.373444 0.704 0.096 2.347535e-255 B.cell IGHG2
85 1.389021e-254 2.110948 0.724 0.108 3.076125e-250 B.cell JCHAIN
86 2.825601e-236 1.853306 0.464 0.037 6.257577e-232 B.cell IGHM
87 5.714481e-232 2.779312 0.978 0.492 1.265529e-227 B.cell IGKC
88 2.819234e-227 1.661483 0.730 0.131 6.243475e-223 B.cell IGHG3
89 7.548871e-214 2.044464 0.795 0.191 1.671773e-209 B.cell IGHG1
90 3.260554e-207 0.839186 0.540 0.063 7.220822e-203 B.cell FCRL5
91 2.893371e-198 1.019215 0.367 0.024 6.407660e-194 B.cell TNFRSF13C
92 7.373843e-187 1.051767 0.721 0.139 1.633011e-182 B.cell MZB1
93 5.848368e-170 1.582415 0.261 0.011 1.295180e-165 B.cell MS4A1
94 3.535579e-156 0.904639 0.767 0.175 7.829893e-152 B.cell MEF2C
95 1.505586e-112 0.766768 0.635 0.179 3.334271e-108 B.cell BASP1
96 3.358071e-110 1.007952 0.263 0.026 7.436784e-106 B.cell DNAAF1
97 4.634418e-99 1.161930 0.719 0.323 1.026338e-94 B.cell XBP1
98 2.388571e-81 0.882670 0.808 0.465 5.289730e-77 B.cell HERPUD1
99 2.091272e-78 1.106643 0.803 0.642 4.631331e-74 B.cell SSR4
100 0.000000e+00 4.582071 1.000 0.001 0.000000e+00 Mast.cell TPSAB1
101 0.000000e+00 3.877009 1.000 0.001 0.000000e+00 Mast.cell TPSB2
102 0.000000e+00 3.806785 1.000 0.000 0.000000e+00 Mast.cell CPA3
103 0.000000e+00 2.914986 1.000 0.000 0.000000e+00 Mast.cell MS4A2
104 0.000000e+00 1.954221 0.500 0.000 0.000000e+00 Mast.cell HDC
105 0.000000e+00 1.879394 0.600 0.000 0.000000e+00 Mast.cell SLC18A2
106 2.708607e-275 1.762342 0.700 0.002 5.998481e-271 Mast.cell IL1RL1
107 8.375732e-232 2.446513 0.800 0.004 1.854890e-227 Mast.cell HPGDS
108 2.795320e-116 3.062042 0.400 0.002 6.190517e-112 Mast.cell CTSG
109 1.336842e-90 1.980649 0.400 0.003 2.960569e-86 Mast.cell KIT
110 8.445914e-36 2.385426 0.900 0.052 1.870432e-31 Mast.cell RHEX
111 2.762328e-31 2.276707 0.800 0.046 6.117452e-27 Mast.cell LTC4S
112 3.842732e-13 2.474078 0.300 0.015 8.510114e-09 Mast.cell HPGD
113 6.607094e-10 2.010808 0.600 0.086 1.463207e-05 Mast.cell EGR1
114 1.139440e-09 1.747879 0.600 0.091 2.523404e-05 Mast.cell BMP2K
115 1.065012e-08 2.135230 0.900 0.253 2.358575e-04 Mast.cell CD69
116 2.436962e-06 1.848910 0.800 0.302 5.396895e-02 Mast.cell LMO4
117 1.013020e-04 2.272498 0.600 0.188 1.000000e+00 Mast.cell AREG
118 1.549851e-04 1.764209 0.700 0.341 1.000000e+00 Mast.cell PPP1R15A
119 1.642752e-03 1.727898 0.500 0.179 1.000000e+00 Mast.cell GADD45B
120 0.000000e+00 3.612032 0.945 0.009 0.000000e+00 Endothelial.cell VWF
121 0.000000e+00 3.219993 0.945 0.033 0.000000e+00 Endothelial.cell SPARCL1
122 0.000000e+00 3.148518 0.577 0.008 0.000000e+00 Endothelial.cell FABP4
123 0.000000e+00 3.087788 0.933 0.057 0.000000e+00 Endothelial.cell A2M
124 0.000000e+00 2.775750 0.810 0.015 0.000000e+00 Endothelial.cell AQP1
125 0.000000e+00 2.694803 0.871 0.043 0.000000e+00 Endothelial.cell ENG
126 0.000000e+00 2.579460 0.503 0.002 0.000000e+00 Endothelial.cell ACKR1
127 0.000000e+00 2.567179 0.902 0.043 0.000000e+00 Endothelial.cell EGFL7
128 0.000000e+00 2.550154 0.712 0.004 0.000000e+00 Endothelial.cell COL15A1
129 0.000000e+00 2.355471 0.847 0.014 0.000000e+00 Endothelial.cell CD34
130 0.000000e+00 2.307173 0.564 0.013 0.000000e+00 Endothelial.cell CLDN5
131 0.000000e+00 2.286874 0.810 0.042 0.000000e+00 Endothelial.cell SPARC
132 0.000000e+00 2.264955 0.810 0.001 0.000000e+00 Endothelial.cell CLEC14A
133 0.000000e+00 2.210030 0.693 0.005 0.000000e+00 Endothelial.cell PLVAP
134 1.180073e-271 3.073876 0.951 0.099 2.613390e-267 Endothelial.cell HSPG2
135 1.645477e-229 2.609952 0.951 0.125 3.644074e-225 Endothelial.cell PECAM1
136 1.862517e-197 3.146641 0.933 0.141 4.124730e-193 Endothelial.cell IGFBP7
137 1.946650e-157 2.974384 0.859 0.151 4.311052e-153 Endothelial.cell COL4A1
138 2.104511e-133 2.517474 0.785 0.149 4.660651e-129 Endothelial.cell CAV1
139 2.478821e-119 2.350341 0.779 0.160 5.489596e-115 Endothelial.cell COL4A2
140 0.000000e+00 5.303753 0.965 0.035 0.000000e+00 Fibroblast COL1A1
141 0.000000e+00 4.944681 0.958 0.013 0.000000e+00 Fibroblast COL3A1
142 0.000000e+00 4.904891 0.972 0.021 0.000000e+00 Fibroblast COL1A2
143 0.000000e+00 3.692744 0.782 0.003 0.000000e+00 Fibroblast DCN
144 0.000000e+00 3.608571 0.810 0.036 0.000000e+00 Fibroblast CCDC80
145 0.000000e+00 3.180768 0.817 0.027 0.000000e+00 Fibroblast MGP
146 0.000000e+00 3.164980 0.972 0.069 0.000000e+00 Fibroblast COL6A2
147 0.000000e+00 3.050403 0.711 0.003 0.000000e+00 Fibroblast LUM
148 0.000000e+00 2.948451 0.958 0.041 0.000000e+00 Fibroblast SPARC
149 0.000000e+00 2.819481 0.775 0.008 0.000000e+00 Fibroblast COL6A3
150 0.000000e+00 2.695115 0.408 0.003 0.000000e+00 Fibroblast C7
151 0.000000e+00 2.591463 0.423 0.001 0.000000e+00 Fibroblast SFRP2
152 0.000000e+00 2.493010 0.923 0.038 0.000000e+00 Fibroblast SPARCL1
153 0.000000e+00 2.278685 0.718 0.016 0.000000e+00 Fibroblast MMP2
154 2.739688e-279 2.956295 0.930 0.075 6.067312e-275 Fibroblast COL6A1
155 4.629681e-173 2.656972 0.768 0.086 1.025289e-168 Fibroblast FBLN1
156 5.276213e-161 2.584274 0.986 0.194 1.168470e-156 Fibroblast CALD1
157 1.001618e-102 2.329021 0.880 0.231 2.218184e-98 Fibroblast TIMP1
158 2.165322e-102 2.655018 0.690 0.123 4.795322e-98 Fibroblast C3
159 4.773170e-82 2.226566 0.845 0.274 1.057066e-77 Fibroblast LGALS1
160 0.000000e+00 4.052812 0.963 0.006 0.000000e+00 Ovarian.cancer.cell WFDC2
161 0.000000e+00 3.497681 0.823 0.002 0.000000e+00 Ovarian.cancer.cell MMP7
162 0.000000e+00 2.940807 0.848 0.009 0.000000e+00 Ovarian.cancer.cell SLPI
163 0.000000e+00 2.809882 0.907 0.003 0.000000e+00 Ovarian.cancer.cell KRT7
164 0.000000e+00 2.688646 0.922 0.018 0.000000e+00 Ovarian.cancer.cell CD24
165 0.000000e+00 2.560454 0.923 0.004 0.000000e+00 Ovarian.cancer.cell C19orf33
166 0.000000e+00 2.552963 0.992 0.748 0.000000e+00 Ovarian.cancer.cell GAPDH
167 0.000000e+00 2.439130 0.871 0.003 0.000000e+00 Ovarian.cancer.cell EPCAM
168 0.000000e+00 2.433767 0.841 0.015 0.000000e+00 Ovarian.cancer.cell KRT19
169 0.000000e+00 2.359114 0.887 0.029 0.000000e+00 Ovarian.cancer.cell KRT18
170 0.000000e+00 2.339751 0.902 0.088 0.000000e+00 Ovarian.cancer.cell SPINT2
171 0.000000e+00 2.308219 0.912 0.087 0.000000e+00 Ovarian.cancer.cell MDK
172 0.000000e+00 2.271744 0.817 0.003 0.000000e+00 Ovarian.cancer.cell CLDN3
173 0.000000e+00 2.224701 0.920 0.040 0.000000e+00 Ovarian.cancer.cell CDKN2A
174 0.000000e+00 2.183538 0.903 0.114 0.000000e+00 Ovarian.cancer.cell GLO1
175 0.000000e+00 2.161995 0.899 0.023 0.000000e+00 Ovarian.cancer.cell KRT8
176 0.000000e+00 2.078171 0.943 0.427 0.000000e+00 Ovarian.cancer.cell GSTP1
177 0.000000e+00 1.995567 0.952 0.241 0.000000e+00 Ovarian.cancer.cell MTCH1
178 0.000000e+00 1.993618 0.581 0.001 0.000000e+00 Ovarian.cancer.cell KRT17
179 0.000000e+00 1.947691 0.941 0.356 0.000000e+00 Ovarian.cancer.cell TPI1

Cell Type



B-cell

-5 0 5 -5 0 5 10 UMAP-1 UMAP-2 TEST_IOP TEST_RAP Sample -5 0 5 -5 0 5 10 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -5 0 5 -5 0 5 10 UMAP-1 UMAP-2 0 1 2 3 4 Cluster





Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 1.686776e-34 0.706326 1.000 0.969 3.735533e-30 0 IGKC
1 5.943530e-19 0.551291 1.000 0.717 1.316254e-14 0 SSR4
2 2.037374e-15 0.818085 0.711 0.302 4.511969e-11 0 IGKV3-11
3 5.961873e-14 0.447104 0.979 0.558 1.320316e-09 0 ITM2C
4 7.907461e-14 0.506131 0.979 0.620 1.751186e-09 0 IGHG3
5 1.091119e-13 0.595055 0.986 0.710 2.416392e-09 0 IGHG1
6 1.647426e-13 0.488759 0.880 0.483 3.648390e-09 0 IFI27
7 2.065240e-13 0.429868 0.993 0.598 4.573681e-09 0 XBP1
8 5.733713e-13 0.445307 1.000 0.598 1.269788e-08 0 MZB1
9 4.648785e-12 0.312734 0.979 0.611 1.029520e-07 0 JCHAIN
10 8.122534e-12 0.411116 0.972 0.558 1.798816e-07 0 PRDX4
11 2.101004e-11 0.547999 0.690 0.324 4.652882e-07 0 IGHV1-24
12 3.434599e-11 0.289843 0.937 0.592 7.606263e-07 0 IGHG4
13 2.033623e-10 0.320652 0.951 0.539 4.503661e-06 0 FKBP11
14 1.140962e-08 0.297976 0.958 0.698 2.526774e-04 0 IFI6
15 1.486213e-08 0.253588 0.796 0.467 3.291368e-04 0 PRDM1
16 1.519887e-08 0.267483 0.894 0.498 3.365941e-04 0 DERL3
17 3.243440e-08 0.302603 0.986 0.611 7.182922e-04 0 SEC11C
18 2.420898e-07 0.254445 0.915 0.561 5.361321e-03 0 FKBP2
19 3.761997e-17 0.531297 0.981 0.553 8.331319e-13 1 TENT5C
20 4.452833e-15 0.618469 1.000 0.637 9.861244e-11 1 XBP1
21 7.616366e-15 0.633262 0.905 0.497 1.686720e-10 1 ANKRD28
22 2.714719e-14 0.574542 1.000 0.751 6.012016e-10 1 HERPUD1
23 8.811754e-14 0.683448 0.952 0.648 1.951451e-09 1 RGS1
24 2.065005e-13 0.502956 0.581 0.229 4.573159e-09 1 CEP128
25 1.225519e-12 0.492876 0.848 0.458 2.714034e-08 1 DUSP5
26 2.520611e-12 0.507535 0.895 0.567 5.582144e-08 1 CD38
27 6.620819e-12 0.594386 1.000 0.737 1.466247e-07 1 HSP90B1
28 7.857804e-12 0.548940 1.000 0.640 1.740189e-07 1 MZB1
29 1.080017e-11 0.516513 0.962 0.651 2.391805e-07 1 PPIB
30 1.613904e-11 0.587214 0.990 0.743 3.574152e-07 1 BTG2
31 3.975847e-10 0.731587 0.838 0.536 8.804911e-06 1 IFI27
32 1.284407e-09 0.685993 0.981 0.648 2.844448e-05 1 JCHAIN
33 3.752606e-09 0.594652 0.943 0.729 8.310522e-05 1 IFI6
34 7.583540e-09 0.744472 0.895 0.606 1.679451e-04 1 JUN
35 8.135711e-09 0.931761 0.476 0.201 1.801735e-04 1 DNAAF1
36 8.579877e-09 0.652514 0.857 0.561 1.900099e-04 1 NFKBIA
37 3.902604e-08 0.489759 0.876 0.592 8.642706e-04 1 RRBP1
38 1.313818e-06 0.515108 0.648 0.372 2.909582e-02 1 ZFP36
39 6.961778e-45 1.577603 1.000 0.965 1.541755e-40 2 RPL32
40 9.530631e-45 1.675012 0.989 0.965 2.110654e-40 2 RPL30
41 5.043881e-44 1.754034 1.000 0.989 1.117018e-39 2 RPS27
42 2.178105e-42 1.629310 1.000 0.989 4.823632e-38 2 RPS29
43 2.234141e-42 1.643633 0.989 0.957 4.947729e-38 2 RPLP2
44 5.672910e-42 1.698868 1.000 0.336 1.256323e-37 2 HLA-DRA
45 6.515390e-42 1.697845 0.978 0.911 1.442898e-37 2 RPL38
46 2.004909e-41 1.577687 0.824 0.142 4.440072e-37 2 HLA-DQA1
47 3.467828e-41 1.547253 1.000 0.952 7.679853e-37 2 RPS23
48 1.192651e-40 2.241705 0.956 0.688 2.641245e-36 2 BTG1
49 3.045780e-38 1.707857 0.923 0.296 6.745185e-34 2 HLA-DRB1
50 1.555791e-36 1.814336 0.956 0.702 3.445455e-32 2 CXCR4
51 1.099437e-32 1.812542 0.967 0.777 2.434813e-28 2 TXNIP
52 1.852332e-31 1.881576 0.824 0.352 4.102174e-27 2 CD37
53 5.875714e-31 1.877251 0.648 0.148 1.301236e-26 2 VPREB3
54 4.288547e-25 1.604690 0.396 0.035 9.497417e-21 2 IFIT2
55 2.861301e-24 1.694809 0.560 0.118 6.336637e-20 2 CD69
56 4.312681e-23 1.560631 0.615 0.185 9.550864e-19 2 TRIM22
57 7.169604e-18 1.577779 0.637 0.301 1.587781e-13 2 TNFRSF13C
58 4.630724e-17 1.607544 0.593 0.261 1.025520e-12 2 IFITM2
59 7.842567e-15 1.137239 0.958 0.658 1.736815e-10 3 IGHG2
60 8.350033e-15 0.679229 0.958 0.765 1.849198e-10 3 IGHG1
61 8.604989e-14 0.694096 0.944 0.622 1.905661e-09 3 JUN
62 1.016864e-13 0.571230 0.958 0.689 2.251946e-09 3 IGHG3
63 2.105211e-11 0.654289 0.676 0.304 4.662200e-07 3 IGLV3-1
64 4.028393e-11 0.547931 0.986 0.564 8.921280e-07 3 NFKBIA
65 5.372683e-11 0.485243 0.958 0.607 1.189834e-06 3 FOSB
66 1.162150e-10 0.512571 0.930 0.528 2.573696e-06 3 ANKRD28
67 1.803110e-10 0.481446 1.000 0.768 3.993167e-06 3 SSR4
68 1.862193e-10 0.511923 1.000 0.974 4.124012e-06 3 IGKC
69 4.658326e-09 0.644647 0.718 0.365 1.031633e-04 3 CYTOR
70 2.059572e-08 0.679270 0.761 0.393 4.561128e-04 3 IER2
71 2.800799e-07 0.861363 0.873 0.564 6.202650e-03 3 IGHGP
72 5.642314e-07 0.537263 0.986 0.676 1.249547e-02 3 JCHAIN
73 6.596225e-07 0.561082 0.930 0.656 1.460800e-02 3 IGHG4
74 1.338946e-06 0.494438 0.423 0.161 2.965229e-02 3 ATF3
75 7.546897e-06 0.601051 0.676 0.393 1.671336e-01 3 IGHV1-24
76 1.830121e-04 0.446440 0.986 0.765 1.000000e+00 3 BTG2
77 8.145419e-04 0.451019 0.648 0.388 1.000000e+00 3 IGKV3-11
78 2.430567e-03 0.470787 0.634 0.452 1.000000e+00 3 AREG
79 6.513274e-41 2.240652 0.815 0.103 1.442430e-36 4 LTB
80 1.529305e-30 1.719377 0.870 0.181 3.386799e-26 4 MS4A1
81 2.878635e-30 1.720138 0.778 0.159 6.375025e-26 4 LCP1
82 3.883265e-28 2.043709 1.000 0.775 8.599879e-24 4 ACTB
83 7.045720e-27 1.522645 0.926 0.257 1.560345e-22 4 HLA-DPB1
84 7.976431e-26 1.656953 1.000 0.941 1.766460e-21 4 CD74
85 8.543102e-26 2.013869 0.944 0.523 1.891955e-21 4 HLA-DPA1
86 4.584572e-25 2.000967 1.000 0.978 1.015299e-20 4 MT-CO3
87 1.788675e-23 1.582539 1.000 0.995 3.961199e-19 4 MT-CO2
88 4.429927e-23 1.741096 1.000 0.988 9.810517e-19 4 MT-CO1
89 8.978685e-23 1.515882 0.963 0.401 1.988420e-18 4 HLA-DRA
90 1.237477e-22 1.720432 1.000 0.983 2.740516e-18 4 MT-ATP6
91 1.807630e-21 1.499003 0.889 0.433 4.003178e-17 4 PTPRC
92 1.879343e-21 1.554018 0.870 0.374 4.161993e-17 4 HLA-DQB1
93 5.845108e-20 1.551354 0.981 0.978 1.294458e-15 4 MT-ND4
94 2.212288e-15 1.872194 0.815 0.575 4.899333e-11 4 ITGB1
95 3.191294e-15 1.810414 0.815 0.577 7.067439e-11 4 ACTG1
96 1.489755e-14 1.535755 0.704 0.340 3.299211e-10 4 POU2F2
97 2.916576e-12 2.689747 0.741 0.474 6.459049e-08 4 PLCG2
98 1.167544e-07 1.509384 0.259 0.061 2.585644e-03 4 MIR155HG
Endothelial-cell

-6 -3 0 3 -2 -1 0 1 2 UMAP-1 UMAP-2 TEST_IOP TEST_ION TEST_RAP Sample -6 -3 0 3 -2 -1 0 1 2 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -6 -3 0 3 -2 -1 0 1 2 UMAP-1 UMAP-2 0 1 Cluster





Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 1.801466e-26 1.443674 1.000 0.838 3.989528e-22 0 RPS28
1 6.327663e-25 1.548753 1.000 0.588 1.401324e-20 0 RPL41
2 2.245890e-23 1.399283 1.000 0.612 4.973749e-19 0 RPLP1
3 2.347039e-23 1.607706 0.976 0.412 5.197751e-19 0 RPL30
4 3.938832e-23 1.812968 0.964 0.200 8.722937e-19 0 RPS13
5 6.184706e-23 1.592143 0.988 0.462 1.369665e-18 0 RPS4X
6 7.257837e-23 1.635448 0.988 0.438 1.607321e-18 0 RPL39
7 8.084042e-23 1.444296 1.000 0.750 1.790292e-18 0 RPL10
8 9.961047e-23 1.636462 0.976 0.450 2.205974e-18 0 RPS12
9 2.058981e-22 1.506575 0.988 0.512 4.559819e-18 0 RPL36
10 3.656061e-22 1.412072 1.000 0.500 8.096712e-18 0 RPS3
11 6.916286e-22 1.499274 0.988 0.425 1.531681e-17 0 RPS15A
12 1.397217e-21 1.398284 1.000 0.712 3.094278e-17 0 RPS18
13 1.464414e-21 1.641055 0.940 0.250 3.243091e-17 0 RPL26
14 3.873394e-21 1.561772 0.988 0.362 8.578019e-17 0 RPL29
15 4.720720e-21 1.503590 1.000 0.362 1.045451e-16 0 RPL35A
16 8.468019e-21 1.507756 0.976 0.612 1.875328e-16 0 RPL34
17 2.858599e-19 1.429963 1.000 0.650 6.330653e-15 0 RPL32
18 1.738321e-07 1.436067 0.699 0.225 3.849686e-03 0 MGP
19 4.129932e-06 1.509046 0.723 0.425 9.146147e-02 0 FABP4
20 7.948592e-16 0.807396 1.000 1.000 1.760295e-11 1 MT-ND3
21 4.992188e-13 1.201218 0.950 0.952 1.105570e-08 1 NEAT1
22 3.118551e-11 0.702526 0.988 0.976 6.906343e-07 1 MT-ND5
23 4.123039e-11 1.148848 0.875 0.892 9.130883e-07 1 XIST
24 9.588669e-11 0.829184 0.975 0.964 2.123507e-06 1 MTRNR2L12
25 1.803771e-07 1.066268 0.762 0.699 3.994630e-03 1 LAMB1
26 1.020010e-04 0.713567 0.712 0.663 1.000000e+00 1 PLXND1
27 1.946204e-04 0.727838 0.600 0.470 1.000000e+00 1 FLNB
28 2.866860e-04 0.870655 0.612 0.566 1.000000e+00 1 CFLAR
29 3.274126e-04 0.792694 0.675 0.578 1.000000e+00 1 NKTR
30 6.176386e-04 0.662747 0.688 0.675 1.000000e+00 1 ROBO4
31 7.614619e-04 0.724258 0.588 0.518 1.000000e+00 1 ATRX
32 8.591192e-04 0.862342 0.475 0.337 1.000000e+00 1 ZNF638
33 1.676264e-03 0.823444 0.488 0.361 1.000000e+00 1 CCNL2
34 2.479554e-03 0.880563 0.438 0.313 1.000000e+00 1 SPG7
35 3.581719e-03 0.754232 0.600 0.614 1.000000e+00 1 COL18A1
36 3.861889e-03 0.811690 0.450 0.349 1.000000e+00 1 MT-ND6
37 4.055410e-03 0.774354 0.825 0.892 1.000000e+00 1 COL4A1
38 4.812443e-03 0.701257 0.525 0.506 1.000000e+00 1 SHANK3
39 8.328474e-03 1.160703 0.388 0.265 1.000000e+00 1 KCNQ1OT1
Fibroblast

-10 -5 0 5 -5 0 5 10 UMAP-1 UMAP-2 TEST_IOP TEST_ION TEST_ASN TEST_RAP Sample -10 -5 0 5 -5 0 5 10 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -10 -5 0 5 -5 0 5 10 UMAP-1 UMAP-2 0 1 2 3 Cluster

UV RESPONSE DN Fibroblast −5 0 5 10 15 Normalized Enrichment Score 0 Common Genes

0 2 4 6 8 10 12 14 16 18 -log(Adjusted P-value) 10 HALLMARK_UV_RESPONSE_DN HALLMARK_APOPTOSIS HALLMARK_COAGULATION HALLMARK_ANGIOGENESIS HALLMARK_MYOGENESIS HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION Fibroblast

Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 4.189222e-10 1.122596 0.943 0.742 9.277450e-06 0 MGP
1 1.100908e-09 0.810345 0.962 0.607 2.438072e-05 0 RARRES2
2 1.501747e-08 0.954503 0.943 0.573 3.325768e-04 0 LUM
3 4.509006e-08 0.905971 0.887 0.562 9.985644e-04 0 HTRA1
4 5.240893e-08 0.673624 0.943 0.618 1.160648e-03 0 SERPINF1
5 9.895324e-08 1.249382 0.717 0.315 2.191419e-03 0 CTHRC1
6 2.064719e-07 1.118319 0.736 0.303 4.572526e-03 0 PTGDS
7 5.106769e-07 0.795259 0.585 0.213 1.130945e-02 0 MFAP2
8 1.024029e-06 1.011127 0.717 0.360 2.267814e-02 0 CTSK
9 1.038619e-06 0.706458 1.000 0.697 2.300125e-02 0 CCDC80
10 1.100282e-05 0.727010 0.755 0.427 2.436685e-01 0 OGN
11 1.505321e-05 0.675728 0.642 0.303 3.333684e-01 0 COL8A1
12 1.575596e-05 0.962330 0.774 0.427 3.489316e-01 0 IGF1
13 5.135076e-05 0.761069 0.792 0.461 1.000000e+00 0 SPON2
14 8.538305e-05 1.052172 0.623 0.303 1.000000e+00 0 SFRP2
15 2.821963e-04 0.675008 0.453 0.213 1.000000e+00 0 GAS1
16 3.244839e-04 0.813948 0.585 0.303 1.000000e+00 0 C7
17 2.295766e-03 1.539600 0.415 0.202 1.000000e+00 0 SFRP4
18 2.787040e-03 0.754033 0.623 0.360 1.000000e+00 0 RARRES1
19 8.062285e-03 0.685567 0.321 0.157 1.000000e+00 0 ITM2A
20 2.422584e-13 1.234142 0.971 0.963 5.365055e-09 1 MT-ND5
21 2.180596e-11 1.066897 1.000 1.000 4.829148e-07 1 MT-ATP6
22 3.423031e-11 1.074354 1.000 1.000 7.580644e-07 1 MT-ND3
23 2.469076e-10 0.933721 1.000 1.000 5.468015e-06 1 MT-ND4
24 4.273604e-10 0.917429 1.000 1.000 9.464325e-06 1 MT-CO3
25 4.404936e-10 0.889839 1.000 1.000 9.755170e-06 1 MT-CYB
26 4.894321e-10 0.913632 0.971 0.972 1.083896e-05 1 MT-ND4L
27 5.931581e-09 0.999041 0.943 0.925 1.313608e-04 1 MTRNR2L12
28 6.667348e-06 1.607088 0.771 0.794 1.476551e-01 1 XIST
29 1.173489e-05 1.014913 0.857 0.748 2.598809e-01 1 COL6A3
30 6.400621e-05 0.906178 0.743 0.692 1.000000e+00 1 MACF1
31 9.230311e-05 1.042339 0.771 0.692 1.000000e+00 1 MEG3
32 1.174193e-04 1.120358 0.629 0.523 1.000000e+00 1 LAMB1
33 2.073149e-03 1.134135 0.514 0.383 1.000000e+00 1 SSC5D
34 2.937739e-03 0.974883 0.371 0.187 1.000000e+00 1 PTPRF
35 3.264986e-03 1.016608 0.629 0.589 1.000000e+00 1 MT-ATP8
36 3.688862e-03 0.871894 0.486 0.364 1.000000e+00 1 GTF3C1
37 4.182730e-03 0.896666 0.657 0.626 1.000000e+00 1 MXRA5
38 4.804168e-03 0.885357 0.629 0.692 1.000000e+00 1 TCF25
39 6.575862e-03 0.953891 0.743 0.673 1.000000e+00 1 C3
40 4.136962e-10 0.862400 0.903 0.279 9.161716e-06 2 S100A16
41 2.212077e-09 1.095115 0.968 0.505 4.898866e-05 2 SH3BGRL3
42 3.413760e-09 1.136515 0.968 0.577 7.560113e-05 2 S100A10
43 5.438833e-09 0.921848 1.000 0.838 1.204484e-04 2 TMSB4X
44 1.054540e-07 1.174249 0.968 0.586 2.335383e-03 2 IFI27
45 2.111383e-07 0.855141 0.484 0.081 4.675868e-03 2 UAP1
46 2.554850e-07 0.844352 0.710 0.171 5.657971e-03 2 ALDH1A3
47 1.184160e-05 0.885486 0.419 0.090 2.622441e-01 2 ATF3
48 2.205458e-05 0.842608 1.000 0.820 4.884207e-01 2 S100A6
49 3.477644e-05 0.958213 0.710 0.324 7.701590e-01 2 FOS
50 3.746114e-05 1.050357 0.774 0.396 8.296145e-01 2 JUNB
51 4.490393e-05 0.855316 0.516 0.144 9.944424e-01 2 IFIT3
52 7.251424e-05 0.835925 0.677 0.243 1.000000e+00 2 PLIN2
53 8.675435e-05 1.081472 0.548 0.198 1.000000e+00 2 KRT19
54 8.930139e-05 0.973048 0.903 0.432 1.000000e+00 2 LDHA
55 1.151397e-04 0.843999 0.452 0.135 1.000000e+00 2 SOD2
56 3.472400e-04 0.848108 0.581 0.225 1.000000e+00 2 PLAT
57 6.580936e-04 1.040000 0.871 0.468 1.000000e+00 2 IGFBP6
58 6.798947e-04 0.868525 0.677 0.279 1.000000e+00 2 IFI6
59 1.487430e-03 1.557353 0.548 0.225 1.000000e+00 2 ISG15
60 5.344359e-25 2.074776 0.826 0.008 1.183562e-20 3 PPP1R14A
61 3.605979e-21 1.853171 0.826 0.034 7.985801e-17 3 TINAGL1
62 2.739335e-20 2.110291 0.783 0.034 6.066531e-16 3 NDUFA4L2
63 1.458069e-18 1.727062 0.826 0.059 3.229040e-14 3 MCAM
64 1.277433e-16 2.116527 0.870 0.118 2.829004e-12 3 RGS5
65 5.500532e-16 1.646248 0.826 0.092 1.218148e-11 3 C11orf96
66 1.412729e-14 2.820944 1.000 0.403 3.128631e-10 3 TAGLN
67 2.734313e-14 2.091752 1.000 0.462 6.055410e-10 3 MYL9
68 1.001517e-12 1.734134 0.913 0.286 2.217960e-08 3 COL4A2
69 2.282940e-12 2.964498 0.957 0.437 5.055800e-08 3 ACTA2
70 1.311359e-11 1.812427 0.913 0.353 2.904135e-07 3 CRIP1
71 2.509932e-11 1.671631 0.957 0.689 5.558495e-07 3 TPM2
72 3.038147e-11 1.907310 0.957 0.866 6.728281e-07 3 IGFBP7
73 3.338638e-11 1.885340 0.826 0.244 7.393748e-07 3 MEF2C
74 9.673009e-11 1.643066 0.522 0.042 2.142185e-06 3 STEAP4
75 7.639199e-10 1.797199 0.739 0.202 1.691777e-05 3 PDGFA
76 1.319353e-09 1.679837 0.522 0.067 2.921840e-05 3 PHLDA2
77 1.139925e-08 2.041433 0.435 0.042 2.524478e-04 3 CD36
78 1.149794e-06 1.620365 0.826 0.546 2.546333e-02 3 ADIRF
79 1.504269e-05 2.146533 0.348 0.059 3.331353e-01 3 FABP4
Monocyte

-2.5 0.0 2.5 5.0 -5.0 -2.5 0.0 2.5 UMAP-1 UMAP-2 TEST_IOP TEST_ASN TEST_RAP Sample -2.5 0.0 2.5 5.0 -5.0 -2.5 0.0 2.5 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -2.5 0.0 2.5 5.0 -5.0 -2.5 0.0 2.5 UMAP-1 UMAP-2 0 1 2 3 Cluster





Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 4.868914e-15 0.978392 0.650 0.330 1.078270e-10 0 GSN
1 6.377071e-15 0.742203 0.979 0.962 1.412266e-10 0 HLA-DRA
2 6.902042e-15 0.763034 0.965 0.871 1.528526e-10 0 HLA-DPA1
3 3.766512e-14 1.233214 0.538 0.191 8.341317e-10 0 HLA-DRB5
4 2.796475e-13 0.792020 0.937 0.847 6.193074e-09 0 HLA-DPB1
5 1.794456e-12 0.535767 1.000 0.981 3.974002e-08 0 CD74
6 2.330860e-11 0.876184 0.531 0.201 5.161923e-07 0 HLA-DQA2
7 1.638037e-08 0.654882 0.846 0.718 3.627596e-04 0 HLA-DQB1
8 4.903270e-08 0.610956 0.839 0.584 1.085878e-03 0 HLA-DQA1
9 1.228105e-07 0.888043 0.399 0.167 2.719762e-03 0 ALOX5AP
10 6.792071e-07 1.026552 0.420 0.196 1.504172e-02 0 FN1
11 3.715429e-06 0.557371 0.350 0.153 8.228189e-02 0 HLA-DOA
12 3.942480e-06 0.536853 0.490 0.273 8.731016e-02 0 CD9
13 8.900300e-06 0.752344 0.420 0.234 1.971061e-01 0 ALCAM
14 9.975526e-05 0.872814 0.308 0.158 1.000000e+00 0 C3
15 1.749375e-04 0.737712 0.329 0.177 1.000000e+00 0 CLEC10A
16 1.118148e-03 0.610032 0.497 0.340 1.000000e+00 0 APOC1
17 1.978318e-03 0.666588 0.259 0.139 1.000000e+00 0 SLAMF7
18 2.073495e-03 0.564786 0.455 0.340 1.000000e+00 0 CSF2RA
19 8.213843e-03 0.995450 0.720 0.703 1.000000e+00 0 AC020656.1
20 2.587139e-40 2.101062 0.899 0.165 5.729478e-36 1 IFIT1
21 3.540914e-39 2.269316 0.987 0.341 7.841708e-35 1 ISG15
22 1.099782e-35 1.609077 0.987 0.355 2.435577e-31 1 IFI6
23 6.389158e-35 1.737290 0.810 0.125 1.414943e-30 1 RSAD2
24 2.465725e-34 1.507733 0.899 0.179 5.460595e-30 1 IFIT3
25 1.101106e-32 1.556196 0.975 0.421 2.438509e-28 1 IFITM3
26 4.812149e-32 1.583265 0.975 0.352 1.065699e-27 1 MX1
27 8.011708e-32 1.635742 0.608 0.044 1.774273e-27 1 SDS
28 1.575642e-31 1.445428 0.962 0.399 3.489417e-27 1 LY6E
29 1.424596e-30 1.411419 0.861 0.198 3.154909e-26 1 IL4I1
30 2.050675e-28 1.680364 0.848 0.209 4.541424e-24 1 C15orf48
31 5.623651e-26 1.497732 0.797 0.190 1.245414e-21 1 IFIT2
32 2.738106e-24 1.660815 0.899 0.403 6.063809e-20 1 MT2A
33 3.229794e-24 1.418844 0.911 0.388 7.152702e-20 1 TNFSF10
34 1.920447e-23 1.513095 0.595 0.084 4.253023e-19 1 CXCL11
35 2.147967e-22 1.506013 0.671 0.143 4.756888e-18 1 IL1RN
36 2.009350e-18 1.437957 0.684 0.176 4.449906e-14 1 CXCL10
37 1.182716e-15 1.373729 0.418 0.062 2.619244e-11 1 NUPR1
38 5.362248e-14 1.620042 0.595 0.216 1.187523e-09 1 IFI27
39 1.074396e-11 1.642583 0.304 0.044 2.379357e-07 1 CCL8
40 3.763823e-29 1.356704 0.638 0.078 8.335363e-25 2 RIPOR2
41 1.041280e-28 1.472600 0.928 0.283 2.306019e-24 2 FCN1
42 1.096735e-25 2.474607 0.884 0.346 2.428828e-21 2 S100A9
43 4.269593e-24 2.130060 0.667 0.138 9.455440e-20 2 VCAN
44 4.089651e-23 1.507135 0.855 0.329 9.056940e-19 2 CD55
45 2.463474e-22 1.291488 0.957 0.622 5.455610e-18 2 S100A4
46 1.399985e-19 1.400526 0.565 0.110 3.100407e-15 2 SMIM25
47 4.130819e-19 1.216908 0.319 0.011 9.148111e-15 2 S100A12
48 9.219613e-19 1.257121 0.913 0.650 2.041775e-14 2 NAMPT
49 2.849615e-18 1.068404 0.522 0.092 6.310758e-14 2 CFP
50 2.009633e-17 2.477810 0.623 0.180 4.450533e-13 2 S100A8
51 9.420272e-17 2.087827 0.609 0.177 2.086213e-12 2 THBS1
52 1.241261e-16 1.124906 0.565 0.152 2.748896e-12 2 FGR
53 2.097949e-14 1.242314 0.580 0.187 4.646118e-10 2 LYST
54 2.244195e-14 1.049015 0.899 0.703 4.969994e-10 2 DUSP1
55 2.585096e-13 1.279094 0.841 0.562 5.724954e-09 2 LST1
56 1.339051e-12 1.067108 0.812 0.537 2.965462e-08 2 SAMSN1
57 2.408346e-12 1.099541 0.623 0.276 5.333523e-08 2 IRAK3
58 2.402391e-09 2.033492 0.478 0.173 5.320336e-05 2 IL1B
59 7.685076e-07 1.099507 0.275 0.078 1.701937e-02 2 CDKN1C
60 2.389123e-49 2.394172 1.000 0.110 5.290952e-45 3 SELENOP
61 2.797319e-38 2.091748 0.967 0.227 6.194944e-34 3 MRC1
62 2.210661e-37 1.926670 0.852 0.127 4.895730e-33 3 FOLR2
63 8.580328e-35 1.938057 0.672 0.058 1.900200e-30 3 LILRB5
64 1.133492e-33 2.386569 0.967 0.337 2.510231e-29 3 DAB2
65 1.693524e-33 1.737419 0.951 0.271 3.750479e-29 3 STAB1
66 1.253334e-32 2.175722 0.590 0.034 2.775633e-28 3 LYVE1
67 1.561762e-32 2.120581 0.803 0.137 3.458677e-28 3 SLC40A1
68 3.433070e-32 1.586106 0.672 0.069 7.602877e-28 3 WWP1
69 3.543041e-30 1.659506 0.574 0.041 7.846418e-26 3 COLEC12
70 2.988737e-28 1.577418 0.770 0.141 6.618857e-24 3 MAF
71 5.505481e-28 1.661056 0.787 0.158 1.219244e-23 3 NRP1
72 3.336978e-27 2.060989 0.721 0.131 7.390071e-23 3 F13A1
73 2.026122e-26 1.913156 0.902 0.354 4.487051e-22 3 LGMN
74 3.889217e-24 1.391326 0.689 0.131 8.613059e-20 3 FUCA1
75 6.606637e-24 1.363075 0.770 0.182 1.463106e-19 3 VSIG4
76 1.158574e-23 1.494006 0.984 0.402 2.565777e-19 3 RNASE1
77 7.448359e-23 1.409772 0.934 0.605 1.649514e-18 3 FCGRT
78 5.836767e-11 1.408089 0.754 0.402 1.292610e-06 3 JUN
79 4.790765e-09 1.435238 0.426 0.127 1.060963e-04 3 MARCO
Ovarian-cancer-cell

-5 0 5 10 -10 -5 0 5 10 UMAP-1 UMAP-2 TEST_ION TEST_ASN TEST_RAP Sample -5 0 5 10 -10 -5 0 5 10 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -5 0 5 10 -10 -5 0 5 10 UMAP-1 UMAP-2 0 1 2 3 4 5 6 7 Cluster





Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 1.020937e-80 0.755032 0.854 0.236 2.260966e-76 0 LRRN2
1 1.418662e-65 0.717817 0.874 0.324 3.141770e-61 0 WNT7A
2 2.137877e-64 1.034993 0.969 0.525 4.734543e-60 0 AKAP12
3 7.455928e-64 1.104938 0.996 0.656 1.651190e-59 0 MT-ND3
4 5.966830e-60 0.712473 0.981 0.488 1.321414e-55 0 ITGB8
5 7.153990e-59 1.054628 0.992 0.654 1.584323e-54 0 MT-CO3
6 4.001284e-58 0.667047 0.828 0.291 8.861242e-54 0 MECOM
7 1.445869e-57 1.034169 0.996 0.638 3.202022e-53 0 MT-CYB
8 8.229258e-55 0.937558 0.992 0.649 1.822451e-50 0 MT-ND4
9 6.372363e-53 0.651047 0.785 0.275 1.411223e-48 0 CDH6
10 2.466246e-52 0.940516 0.989 0.662 5.461747e-48 0 MT-ATP6
11 4.810109e-50 0.874706 0.989 0.676 1.065247e-45 0 MT-CO2
12 2.282210e-47 0.709849 0.966 0.583 5.054183e-43 0 ARHGAP29
13 1.889926e-46 0.744168 0.996 0.711 4.185430e-42 0 MT-ND1
14 6.483516e-46 0.679365 0.992 0.717 1.435839e-41 0 MT-ND2
15 1.200085e-43 0.722261 0.989 0.605 2.657707e-39 0 MT-ND5
16 7.561072e-43 0.680298 0.946 0.551 1.674475e-38 0 TACSTD2
17 3.923176e-42 0.895354 0.908 0.519 8.688265e-38 0 TNFSF10
18 1.642684e-39 0.684998 1.000 0.715 3.637889e-35 0 MT-CO1
19 2.563020e-35 0.664525 0.874 0.416 5.676063e-31 0 ID1
20 3.593533e-58 0.793545 0.971 0.525 7.958238e-54 1 CLDN4
21 6.107576e-56 0.836573 0.979 0.522 1.352584e-51 1 NEAT1
22 8.243063e-56 0.768279 0.992 0.687 1.825509e-51 1 MALAT1
23 3.434224e-52 1.037831 0.868 0.412 7.605432e-48 1 PIM1
24 2.805778e-51 0.633628 0.609 0.155 6.213675e-47 1 IFIT2
25 8.190481e-50 0.719632 0.988 0.750 1.813864e-45 1 SQSTM1
26 2.024718e-49 0.636642 0.774 0.286 4.483942e-45 1 ZBTB20
27 2.188795e-48 0.728980 0.926 0.464 4.847306e-44 1 MUC4
28 7.857317e-48 0.710673 0.827 0.360 1.740081e-43 1 CD55
29 1.869894e-47 0.895490 0.601 0.153 4.141067e-43 1 NUPR1
30 4.510987e-45 0.712496 0.942 0.510 9.990031e-41 1 CDKN1C
31 4.246161e-42 0.785897 0.395 0.072 9.403549e-38 1 TRIB3
32 4.885305e-42 0.639453 0.938 0.552 1.081900e-37 1 CEBPB
33 7.290360e-42 0.698580 0.877 0.462 1.614523e-37 1 DHRS3
34 1.428795e-41 0.705620 0.909 0.549 3.164210e-37 1 PERP
35 3.599793e-41 0.762524 0.914 0.512 7.972103e-37 1 ELF3
36 4.246575e-37 0.727135 0.963 0.743 9.404464e-33 1 ZFAS1
37 6.946174e-35 0.823568 0.770 0.327 1.538300e-30 1 GPRC5A
38 2.724297e-26 0.685029 0.646 0.330 6.033228e-22 1 ATF5
39 8.243523e-19 0.836527 0.609 0.336 1.825611e-14 1 RARRES1
40 9.020809e-73 3.888879 0.886 0.493 1.997748e-68 2 PLCG2
41 2.413744e-35 1.349919 0.959 0.707 5.345477e-31 2 MALAT1
42 1.540804e-21 1.404067 0.585 0.374 3.412264e-17 2 VEGFA
43 5.057517e-20 1.085566 0.342 0.121 1.120038e-15 2 KMT2E-AS1
44 1.040417e-18 1.145508 0.834 0.570 2.304108e-14 2 NEAT1
45 3.786946e-15 1.166108 0.347 0.153 8.386571e-11 2 MAFB
46 1.798229e-14 1.281144 0.435 0.253 3.982358e-10 2 PPP1R15A
47 6.442702e-14 1.486550 0.611 0.527 1.426801e-09 2 JUN
48 6.493735e-14 1.181303 0.570 0.474 1.438103e-09 2 CCNL1
49 1.304047e-13 1.084786 0.788 0.706 2.887942e-09 2 SOX4
50 3.912024e-13 1.314740 0.591 0.526 8.663569e-09 2 TRA2B
51 1.661736e-11 1.337973 0.560 0.500 3.680081e-07 2 IER2
52 4.687239e-11 1.086524 0.451 0.325 1.038036e-06 2 HEXIM1
53 6.830137e-11 1.131568 0.508 0.399 1.512602e-06 2 HSPA1B
54 1.801362e-10 1.102549 0.275 0.126 3.989295e-06 2 GADD45B
55 7.158178e-09 1.287087 0.394 0.274 1.585250e-04 2 HES1
56 2.151038e-07 1.095209 0.425 0.349 4.763689e-03 2 SLC38A2
57 9.097753e-06 1.251531 0.472 0.445 2.014788e-01 2 NFKBIA
58 1.138370e-03 1.285920 0.415 0.411 1.000000e+00 2 HSPA1A
59 2.215284e-03 1.454608 0.363 0.341 1.000000e+00 2 MUC16
60 6.474825e-31 0.606799 0.988 0.891 1.433915e-26 3 ROMO1
61 1.292645e-30 0.615004 0.988 0.903 2.862691e-26 3 ENO1
62 5.451876e-30 0.755750 0.957 0.759 1.207372e-25 3 LDHA
63 1.581892e-27 0.552242 0.988 0.865 3.503258e-23 3 NDUFC1
64 3.113870e-26 0.563559 1.000 0.935 6.895976e-22 3 GSTP1
65 1.079154e-25 0.517548 0.981 0.935 2.389895e-21 3 TPI1
66 9.800877e-25 0.646807 0.888 0.645 2.170502e-20 3 BNIP3
67 5.931204e-24 0.527782 0.975 0.902 1.313525e-19 3 RPS26
68 2.934066e-22 0.516519 1.000 0.980 6.497783e-18 3 TMSB10
69 3.205082e-22 0.692863 0.975 0.821 7.097974e-18 3 KRT19
70 3.017909e-21 0.546799 0.925 0.749 6.683462e-17 3 PGK1
71 1.276508e-20 0.537491 0.981 0.860 2.826954e-16 3 LDHB
72 6.945468e-20 0.514753 0.876 0.676 1.538143e-15 3 FAM162A
73 1.553694e-18 0.520298 0.907 0.703 3.440810e-14 3 ATP5MC3
74 1.410169e-15 0.546790 0.963 0.890 3.122961e-11 3 KRT8
75 2.488901e-14 0.614221 0.975 0.841 5.511921e-10 3 CSTB
76 8.370125e-12 0.541297 0.988 0.873 1.853648e-07 3 KRT18
77 5.916878e-08 0.534412 0.683 0.524 1.310352e-03 3 PTGR1
78 3.770177e-07 0.531349 0.516 0.354 8.349434e-03 3 CCDC146
79 1.497015e-04 0.738226 0.634 0.529 1.000000e+00 3 CRYAB
80 1.532253e-51 1.243292 1.000 0.958 3.393328e-47 4 WFDC2
81 7.595692e-48 1.000190 1.000 0.889 1.682142e-43 4 SPINT2
82 1.409114e-46 1.052635 0.986 0.720 3.120624e-42 4 PDIA6
83 1.351276e-44 1.039399 0.986 0.827 2.992536e-40 4 ITM2B
84 2.309318e-43 1.497841 1.000 0.800 5.114216e-39 4 MMP7
85 5.949322e-40 1.105715 0.924 0.615 1.317537e-35 4 PDIA3
86 5.964993e-40 1.128646 0.959 0.699 1.321007e-35 4 IGFBP2
87 5.998092e-37 0.935686 1.000 0.842 1.328337e-32 4 CALR
88 6.137454e-37 0.916767 0.986 0.858 1.359201e-32 4 CST3
89 1.544625e-35 1.639043 0.979 0.831 3.420726e-31 4 SLPI
90 1.176339e-32 0.878278 0.979 0.872 2.605121e-28 4 B2M
91 3.401482e-31 0.881457 0.938 0.680 7.532922e-27 4 CYBA
92 3.130718e-28 0.978908 0.945 0.752 6.933289e-24 4 MT-CO1
93 5.412161e-27 0.982826 0.986 0.795 1.198577e-22 4 HLA-A
94 1.653429e-26 0.934474 0.752 0.434 3.661683e-22 4 HAPLN3
95 5.921196e-22 0.891441 0.986 0.801 1.311308e-17 4 HLA-C
96 1.003165e-17 0.923511 0.621 0.364 2.221609e-13 4 MTRNR2L1
97 2.678448e-10 0.920752 0.572 0.389 5.931691e-06 4 MYOC
98 1.903331e-09 0.911378 0.386 0.208 4.215117e-05 4 SAA1
99 2.685930e-09 1.120787 0.683 0.529 5.948261e-05 4 LCN2
100 4.085494e-112 1.440358 0.721 0.047 9.047734e-108 5 TOP2A
101 9.773880e-105 1.205650 0.658 0.039 2.164523e-100 5 NUSAP1
102 1.032181e-104 1.392207 0.703 0.050 2.285869e-100 5 MKI67
103 7.526706e-98 1.619404 0.703 0.060 1.666864e-93 5 UBE2C
104 6.429004e-95 1.299774 0.721 0.066 1.423767e-90 5 CDKN3
105 1.305287e-88 1.938993 0.883 0.157 2.890689e-84 5 TPX2
106 1.805665e-88 1.170945 0.775 0.093 3.998826e-84 5 BIRC5
107 3.910066e-85 1.288731 0.784 0.107 8.659233e-81 5 CDC20
108 5.482944e-81 2.114613 0.892 0.186 1.214253e-76 5 CENPF
109 8.422993e-79 1.584993 0.865 0.162 1.865356e-74 5 PTTG1
110 6.790716e-78 1.558495 0.802 0.141 1.503872e-73 5 CCNB1
111 2.561298e-76 1.347057 0.748 0.114 5.672252e-72 5 AURKA
112 7.696216e-74 1.123772 0.541 0.043 1.704404e-69 5 ASPM
113 3.547996e-62 1.557376 0.847 0.230 7.857393e-58 5 HMGB2
114 8.223847e-62 1.443544 0.865 0.248 1.821253e-57 5 CKS2
115 1.241391e-47 1.298733 0.901 0.384 2.749185e-43 5 UBE2S
116 1.120653e-39 1.397978 0.901 0.530 2.481798e-35 5 TUBA1B
117 6.989484e-35 1.133581 0.910 0.529 1.547891e-30 5 TUBB4B
118 3.843900e-26 1.107696 0.712 0.341 8.512702e-22 5 KPNA2
119 4.720455e-06 1.474139 0.640 0.567 1.045392e-01 5 HIST1H4C
120 7.101302e-47 0.833289 1.000 0.984 1.572654e-42 6 RPS12
121 1.150482e-46 0.820137 1.000 0.997 2.547858e-42 6 RPS19
122 1.344334e-46 0.845992 1.000 0.990 2.977163e-42 6 RPL18A
123 6.024019e-45 0.804169 1.000 0.989 1.334079e-40 6 RPLP1
124 6.900738e-44 0.752289 1.000 0.980 1.528237e-39 6 RPL39
125 1.841670e-43 0.862994 1.000 0.995 4.078562e-39 6 RPS27
126 3.522248e-43 0.813007 0.991 0.965 7.800371e-39 6 RPLP0
127 1.025175e-42 0.805105 1.000 0.964 2.270352e-38 6 RPS5
128 9.604141e-42 0.767318 1.000 0.993 2.126933e-37 6 RPS29
129 1.047360e-41 0.745161 1.000 0.962 2.319483e-37 6 UBA52
130 2.782882e-41 0.728038 1.000 0.959 6.162971e-37 6 RPS9
131 9.982165e-41 0.753497 1.000 0.968 2.210650e-36 6 RPS23
132 3.321881e-40 0.783494 0.991 0.959 7.356638e-36 6 RPSA
133 1.474061e-39 0.727729 1.000 0.997 3.264456e-35 6 RPS18
134 4.290417e-39 0.752521 1.000 0.970 9.501557e-35 6 RPLP2
135 4.244413e-38 0.751137 1.000 0.990 9.399678e-34 6 RPL37
136 1.917730e-37 0.752944 1.000 0.967 4.247006e-33 6 RPL27A
137 2.774169e-37 0.889552 1.000 0.991 6.143675e-33 6 GAPDH
138 1.051331e-36 0.768876 1.000 0.966 2.328277e-32 6 RPS3
139 2.583593e-34 0.731336 1.000 0.957 5.721625e-30 6 RPS4X
140 4.174276e-137 1.850689 0.829 0.019 9.244351e-133 7 GAS6
141 1.321404e-114 1.558788 0.756 0.020 2.926382e-110 7 UBB
142 7.330873e-88 1.503694 0.756 0.035 1.623495e-83 7 KLK7
143 6.812526e-43 1.417524 0.732 0.092 1.508702e-38 7 HLA-DPA1
144 1.163576e-36 1.880937 0.878 0.197 2.576855e-32 7 UQCRH
145 7.879060e-33 1.872597 0.829 0.183 1.744897e-28 7 HLA-DRA
146 6.707633e-31 2.192228 0.976 0.361 1.485472e-26 7 CD74
147 1.176836e-29 2.927927 0.951 0.346 2.606220e-25 7 IGFBP7
148 1.244021e-25 1.826010 0.976 0.448 2.755009e-21 7 SAT1
149 4.126292e-23 1.840971 0.805 0.267 9.138087e-19 7 HLA-DRB1
150 2.127803e-22 1.377341 0.902 0.325 4.712233e-18 7 MUC16
151 2.142567e-22 1.977793 0.707 0.174 4.744929e-18 7 GPX3
152 1.277889e-19 2.000635 1.000 0.731 2.830013e-15 7 CLU
153 7.951143e-19 1.522890 0.780 0.327 1.760860e-14 7 GSN
154 9.563495e-18 1.742294 0.951 0.541 2.117932e-13 7 MTRNR2L12
155 2.651869e-15 1.402936 0.805 0.444 5.872829e-11 7 IQGAP1
156 2.774103e-14 1.321586 1.000 0.880 6.143529e-10 7 B2M
157 9.904036e-14 1.315205 0.805 0.446 2.193348e-09 7 MSLN
158 1.548783e-12 1.320644 0.732 0.382 3.429936e-08 7 BHLHE41
159 1.167895e-11 1.365405 0.683 0.311 2.586420e-07 7 RARRES3
Plasma-cell

-3 0 3 6 -2 0 2 4 UMAP-1 UMAP-2 TEST_IOP TEST_RAP Sample -3 0 3 6 -2 0 2 4 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -3 0 3 6 -2 0 2 4 UMAP-1 UMAP-2 0 1 2 3 4 Cluster





Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 2.789341e-44 1.380373 1.000 0.925 6.177276e-40 0 HLA-C
1 1.057351e-43 1.679020 0.991 0.431 2.341609e-39 0 IFI6
2 2.832391e-33 1.520018 0.940 0.384 6.272614e-29 0 ISG15
3 1.621319e-30 1.120001 0.836 0.267 3.590574e-26 0 SOCS3
4 1.231327e-27 1.021340 0.966 0.512 2.726896e-23 0 TSC22D3
5 3.851513e-27 1.171028 0.991 0.502 8.529561e-23 0 IGLC3
6 4.565491e-26 1.650896 0.707 0.203 1.011074e-21 0 IFI27
7 1.697855e-22 0.847190 0.819 0.320 3.760070e-18 0 MX1
8 1.213161e-20 1.059223 0.905 0.520 2.686667e-16 0 ZFP36L2
9 3.752795e-20 1.258402 0.491 0.089 8.310940e-16 0 IGLV6-57
10 1.672775e-15 0.943671 0.784 0.423 3.704528e-11 0 NFKBIA
11 3.062570e-14 0.878753 0.922 0.644 6.782367e-10 0 FOS
12 2.109010e-13 0.833485 0.940 0.665 4.670613e-09 0 IGLC2
13 7.673006e-13 0.851747 0.750 0.452 1.699264e-08 0 JUNB
14 2.803121e-12 1.675425 0.302 0.050 6.207792e-08 0 IGLV1-44
15 2.196156e-11 0.962212 0.543 0.214 4.863608e-07 0 AREG
16 3.109332e-09 1.172404 0.319 0.082 6.885926e-05 0 IGLV2-23
17 4.095620e-08 0.873050 0.603 0.377 9.070161e-04 0 KLF2
18 2.999219e-07 0.943310 0.362 0.146 6.642070e-03 0 DNAAF1
19 1.684813e-05 1.347068 0.534 0.324 3.731188e-01 0 IGHA1
20 1.837814e-15 0.849508 0.989 0.958 4.070024e-11 1 IGKC
21 8.816627e-13 0.363149 1.000 0.987 1.952530e-08 1 MT-ND3
22 1.832858e-12 0.359995 1.000 0.954 4.059048e-08 1 MT-ND1
23 1.527831e-10 0.432500 0.978 0.811 3.383534e-06 1 ERLEC1
24 3.820934e-10 0.624516 0.478 0.150 8.461840e-06 1 IGHV5-51
25 3.224732e-09 1.294353 0.922 0.853 7.141491e-05 1 IGHGP
26 3.164818e-08 0.355189 0.522 0.212 7.008806e-04 1 IGLV3-1
27 1.271386e-07 0.674168 0.889 0.723 2.815612e-03 1 HSP90AA1
28 4.701169e-07 0.791711 0.444 0.218 1.041121e-02 1 HSPA1B
29 6.075925e-07 0.441020 0.511 0.244 1.345574e-02 1 Z93930.2
30 6.194670e-07 0.386723 0.511 0.218 1.371872e-02 1 FAM30A
31 1.208374e-06 0.729282 0.367 0.147 2.676064e-02 1 HSPA1A
32 1.332329e-06 0.627792 0.444 0.215 2.950575e-02 1 DNAJB1
33 6.179619e-06 0.368006 0.922 0.814 1.368538e-01 1 RRBP1
34 3.294714e-05 0.371474 0.300 0.117 7.296474e-01 1 HSPH1
35 3.623411e-05 0.351743 0.856 0.668 8.024405e-01 1 JUN
36 1.650205e-04 0.316799 0.267 0.114 1.000000e+00 1 LINC01480
37 1.987994e-04 0.303656 0.411 0.205 1.000000e+00 1 IGKV1D-8
38 4.644627e-04 0.399118 0.444 0.267 1.000000e+00 1 AHNAK
39 3.443094e-03 0.364567 0.678 0.547 1.000000e+00 1 FOSB
40 4.103390e-25 1.946934 0.882 0.554 9.087367e-21 2 PLCG2
41 2.660470e-23 1.021495 1.000 0.955 5.891877e-19 2 IGKC
42 5.662577e-13 1.627691 0.506 0.176 1.254034e-08 2 IGKV1-5
43 1.487360e-12 0.806323 0.529 0.176 3.293907e-08 2 IGKV1D-8
44 1.629971e-11 1.415541 0.494 0.186 3.609733e-07 2 IGHV3-23
45 1.027114e-06 0.482721 0.541 0.317 2.274648e-02 2 IFNG-AS1
46 1.593279e-06 0.451464 0.906 0.795 3.528475e-02 2 MEF2C
47 4.720962e-06 0.371080 0.906 0.833 1.045504e-01 2 ERLEC1
48 5.394358e-05 0.452296 0.576 0.413 1.000000e+00 2 LARP1B
49 9.870344e-05 0.335352 0.812 0.731 1.000000e+00 2 SEL1L
50 1.231319e-03 0.295023 0.718 0.574 1.000000e+00 2 EIF3J
51 1.612804e-03 0.295833 0.847 0.827 1.000000e+00 2 MYDGF
52 4.294766e-03 0.286297 0.624 0.551 1.000000e+00 2 KTN1
53 5.408606e-03 0.306407 0.576 0.519 1.000000e+00 2 LMO4
54 7.841821e-03 0.260384 0.753 0.782 1.000000e+00 2 NDUFA1
55 8.743374e-03 0.258675 0.647 0.609 1.000000e+00 2 NUCB2
56 7.519379e-32 1.164944 0.519 0.026 1.665242e-27 3 IL32
57 1.358113e-30 1.224499 0.648 0.070 3.007676e-26 3 CD52
58 1.318054e-23 1.458706 0.519 0.058 2.918963e-19 3 CCL5
59 2.856900e-20 1.625314 0.944 0.539 6.326890e-16 3 ACTB
60 1.877851e-18 1.176512 0.796 0.306 4.158688e-14 3 PTPRC
61 8.398204e-15 1.030298 0.778 0.344 1.859866e-10 3 PFN1
62 1.179454e-14 1.366536 0.944 0.755 2.612019e-10 3 TMSB10
63 1.254186e-13 1.001171 1.000 0.971 2.777521e-09 3 MT-CYB
64 1.889158e-13 1.060453 0.667 0.257 4.183729e-09 3 S100A4
65 2.923286e-13 1.651961 0.426 0.085 6.473909e-09 3 CCL4
66 3.512440e-13 1.431934 1.000 0.971 7.778650e-09 3 MT-CO3
67 1.045906e-12 1.031745 0.296 0.035 2.316263e-08 3 LTB
68 1.359787e-12 1.057638 1.000 0.983 3.011384e-08 3 MT-CO1
69 1.546642e-12 1.161875 1.000 0.977 3.425193e-08 3 MT-ATP6
70 1.348040e-11 0.976823 1.000 0.980 2.985369e-07 3 MT-ND4
71 3.333165e-10 0.943331 1.000 0.968 7.381628e-06 3 RPS2
72 1.388695e-07 1.192805 0.630 0.353 3.075404e-03 3 ACTG1
73 2.167998e-07 0.981016 0.778 0.676 4.801248e-03 3 ITGB1
74 2.518574e-06 0.952240 0.852 0.770 5.577633e-02 3 GAPDH
75 8.363161e-05 1.294692 0.704 0.525 1.000000e+00 3 HIST1H4C
76 7.854410e-17 1.111794 1.000 0.591 1.739438e-12 4 IGLC3
77 3.144873e-07 1.184197 0.385 0.116 6.964635e-03 4 IGLV2-23
78 5.949165e-07 1.008427 0.942 0.716 1.317502e-02 4 IGLC2
79 4.900992e-06 0.340664 0.327 0.099 1.085374e-01 4 RGPD2
80 2.513397e-05 0.285624 0.654 0.304 5.566168e-01 4 IFI27
81 2.911210e-05 0.407321 0.942 0.600 6.447165e-01 4 TSC22D3
82 8.816785e-05 0.709204 0.308 0.113 1.000000e+00 4 IGHV4-34
83 3.243097e-04 0.592548 0.519 0.278 1.000000e+00 4 AREG
84 2.030992e-03 0.288258 0.885 0.643 1.000000e+00 4 TP53INP1
85 2.890169e-03 0.528730 0.981 0.962 1.000000e+00 4 IGHG3
T-cell

-2.5 0.0 2.5 5.0 -5.0 -2.5 0.0 2.5 UMAP-1 UMAP-2 TEST_IOP TEST_RAP Sample -2.5 0.0 2.5 5.0 -5.0 -2.5 0.0 2.5 UMAP-1 UMAP-2 PATIENT1 PATIENT2 Batch -2.5 0.0 2.5 5.0 -5.0 -2.5 0.0 2.5 UMAP-1 UMAP-2 0 1 2 3 4 5 6 7 8 9 Cluster





Cluster Markers
p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene
0 7.112276e-91 1.092196 0.954 0.567 1.575085e-86 0 IL7R
1 1.102111e-71 1.042389 0.786 0.304 2.440736e-67 0 KLF2
2 2.313173e-59 0.500243 0.997 0.942 5.122754e-55 0 RPL30
3 1.088868e-47 0.496657 0.992 0.913 2.411406e-43 0 RPL32
4 4.839372e-46 0.915319 0.754 0.446 1.071727e-41 0 JUNB
5 3.169986e-43 0.566566 0.989 0.879 7.020251e-39 0 TXNIP
6 1.499457e-41 0.613181 0.976 0.844 3.320698e-37 0 FTH1
7 1.851338e-37 0.868883 0.638 0.306 4.099973e-33 0 GPR171
8 2.286421e-34 0.734049 0.411 0.131 5.063508e-30 0 CCR7
9 3.098297e-34 0.544103 0.905 0.728 6.861488e-30 0 SARAF
10 4.028227e-34 0.500813 0.970 0.818 8.920910e-30 0 ZFP36L2
11 2.083274e-30 0.684621 0.678 0.379 4.613618e-26 0 ANXA1
12 1.353019e-23 0.537632 0.681 0.383 2.996395e-19 0 CRYBG1
13 1.914089e-22 0.643025 0.476 0.222 4.238942e-18 0 GPR183
14 2.599304e-22 0.591181 0.365 0.147 5.756419e-18 0 SOCS3
15 4.574305e-21 0.569988 0.570 0.324 1.013026e-16 0 FOS
16 2.181870e-18 0.582752 0.322 0.132 4.831970e-14 0 AP3M2
17 1.700965e-16 0.508935 0.668 0.449 3.766957e-12 0 NFKBIA
18 4.007729e-13 0.505757 0.319 0.156 8.875516e-09 0 CDC14A
19 6.390134e-11 0.580928 0.305 0.163 1.415159e-06 0 SELL
20 8.499058e-81 1.151204 0.749 0.238 1.882201e-76 1 CD8A
21 3.099927e-73 0.999755 0.803 0.295 6.865099e-69 1 GZMK
22 1.794116e-47 0.955039 0.479 0.138 3.973250e-43 1 CD8B
23 1.398914e-45 0.845855 0.821 0.392 3.098034e-41 1 CCL4
24 5.324919e-36 0.427279 0.949 0.599 1.179257e-31 1 CCL5
25 6.489349e-34 0.633129 0.764 0.412 1.437131e-29 1 GZMA
26 1.908376e-24 0.741587 0.316 0.106 4.226291e-20 1 ITM2C
27 8.950342e-24 0.864829 0.430 0.210 1.982143e-19 1 PPP1R14B
28 1.611903e-23 0.562417 0.724 0.482 3.569719e-19 1 DUSP2
29 4.107605e-20 0.514315 0.658 0.401 9.096701e-16 1 CST7
30 1.460000e-18 0.615661 0.311 0.122 3.233316e-14 1 CRTAM
31 7.127283e-17 0.548546 0.430 0.219 1.578408e-12 1 ZEB2
32 9.181733e-14 0.497935 0.456 0.284 2.033387e-09 1 GZMM
33 5.857672e-13 0.488737 0.490 0.317 1.297240e-08 1 CLEC2B
34 1.044062e-12 0.572037 0.330 0.179 2.312180e-08 1 GABARAPL1
35 6.209865e-09 0.487700 0.373 0.254 1.375237e-04 1 PIP4K2A
36 7.457113e-09 0.493607 0.322 0.196 1.651452e-04 1 CMC1
37 4.601334e-08 0.448871 0.399 0.283 1.019011e-03 1 TUBA4A
38 1.700580e-06 0.459096 0.385 0.283 3.766105e-02 1 RGCC
39 1.927934e-06 0.464987 0.254 0.160 4.269603e-02 1 MLLT3
40 3.322471e-55 1.188188 0.804 0.395 7.357944e-51 2 IFIT3
41 4.097304e-52 1.052946 0.770 0.329 9.073888e-48 2 GZMK
42 3.521655e-49 0.916741 0.721 0.271 7.799058e-45 2 CD8A
43 1.956278e-47 0.928819 0.774 0.395 4.332372e-43 2 CST7
44 7.350401e-47 0.792294 0.860 0.409 1.627820e-42 2 CCL4
45 8.134844e-45 0.685596 0.947 0.721 1.801542e-40 2 ISG20
46 1.205724e-35 0.907815 0.660 0.345 2.670195e-31 2 IFIT1
47 2.212968e-34 0.853664 0.698 0.386 4.900840e-30 2 MX2
48 8.249999e-34 1.061113 0.562 0.234 1.827045e-29 2 IFIT2
49 8.965492e-26 0.752943 0.283 0.073 1.985498e-21 2 EOMES
50 9.909972e-26 0.830957 0.374 0.121 2.194662e-21 2 CRTAM
51 1.206673e-25 0.690139 0.706 0.468 2.672298e-21 2 SAMD9L
52 1.026285e-20 0.794737 0.362 0.146 2.272810e-16 2 CD38
53 1.348245e-19 0.722686 0.408 0.188 2.985824e-15 2 LAG3
54 4.398420e-19 0.723427 0.460 0.226 9.740740e-15 2 ZEB2
55 6.432870e-19 0.728698 0.396 0.171 1.424623e-14 2 CD8B
56 2.048386e-18 0.692823 0.404 0.189 4.536356e-14 2 CMC1
57 1.111709e-17 0.694723 0.434 0.224 2.461990e-13 2 CLDND1
58 2.726666e-16 0.750493 0.313 0.127 6.038475e-12 2 TRGC2
59 1.797637e-15 0.700554 0.460 0.266 3.981047e-11 2 LYST
60 2.003208e-92 1.742942 0.995 0.934 4.436304e-88 3 MT-CO3
61 3.060244e-90 1.763537 0.995 0.852 6.777216e-86 3 MT-CYB
62 3.655131e-88 1.369820 1.000 0.982 8.094653e-84 3 MT-CO2
63 8.994354e-88 1.545439 1.000 0.964 1.991890e-83 3 MT-ATP6
64 2.309069e-86 1.481968 1.000 0.878 5.113665e-82 3 MT-ND4
65 1.122865e-85 1.305543 1.000 0.982 2.486697e-81 3 MT-CO1
66 2.953244e-84 1.443501 1.000 0.989 6.540255e-80 3 MT-ND3
67 1.429662e-74 1.335083 0.990 0.895 3.166130e-70 3 MT-ND1
68 1.254625e-61 1.121854 0.995 0.861 2.778491e-57 3 MT-ND2
69 1.795031e-61 1.111277 0.937 0.675 3.975277e-57 3 MT-ND5
70 8.155249e-47 1.338005 0.895 0.691 1.806061e-42 3 IGKC
71 9.057461e-44 1.129137 0.764 0.387 2.005865e-39 3 MT-ND4L
72 1.181557e-13 0.791387 0.277 0.105 2.616675e-09 3 MT-ATP8
73 9.623989e-13 0.755589 0.393 0.204 2.131329e-08 3 FLNA
74 3.208800e-12 0.801597 0.429 0.244 7.106208e-08 3 MT-ND6
75 1.105233e-11 0.832110 0.314 0.141 2.447650e-07 3 MTRNR2L8
76 1.762399e-11 0.852687 0.560 0.363 3.903008e-07 3 NKG7
77 2.974952e-10 0.763419 0.314 0.143 6.588329e-06 3 KLRD1
78 4.937786e-07 0.949739 0.340 0.212 1.093522e-02 3 PRF1
79 8.961298e-05 0.714847 0.288 0.185 1.000000e+00 3 AREG
80 2.048584e-122 2.717945 0.650 0.062 4.536794e-118 4 CXCL13
81 1.504632e-53 1.032410 0.435 0.066 3.332158e-49 4 CD40LG
82 1.173009e-46 0.975800 0.333 0.043 2.597745e-42 4 TSHZ2
83 1.388704e-46 1.121668 0.644 0.191 3.075424e-42 4 IL6ST
84 1.382158e-32 0.914011 0.734 0.330 3.060926e-28 4 NR3C1
85 1.524149e-32 0.877773 0.582 0.187 3.375380e-28 4 CTLA4
86 4.691028e-30 0.897814 0.785 0.391 1.038875e-25 4 ARID5B
87 8.255101e-29 0.748329 0.362 0.085 1.828175e-24 4 ADAM19
88 2.082547e-27 0.797722 0.559 0.199 4.612008e-23 4 BTG3
89 2.495250e-27 0.824656 0.571 0.207 5.525981e-23 4 MAF
90 9.499097e-27 0.731055 0.847 0.493 2.103670e-22 4 FKBP5
91 9.855104e-26 0.743860 0.254 0.047 2.182511e-21 4 MFHAS1
92 2.188073e-25 0.769447 0.734 0.368 4.845706e-21 4 ALOX5AP
93 5.094543e-25 0.728228 0.497 0.168 1.128237e-20 4 ICOS
94 1.868654e-23 0.781900 0.379 0.109 4.138321e-19 4 TP53INP1
95 1.924151e-23 0.709915 0.780 0.424 4.261224e-19 4 NAP1L4
96 2.570661e-23 0.772245 0.644 0.300 5.692986e-19 4 RBPJ
97 7.226400e-23 0.827664 0.458 0.160 1.600359e-18 4 PLIN2
98 8.351097e-22 0.695614 0.328 0.087 1.849434e-17 4 PDCD1
99 1.023388e-19 0.804688 0.616 0.306 2.266395e-15 4 RORA
100 2.160344e-209 1.522335 0.602 0.005 4.784297e-205 5 FOXP3
101 5.223961e-139 1.843542 0.534 0.023 1.156898e-134 5 IL2RA
102 3.962339e-111 1.327961 0.557 0.043 8.774996e-107 5 IKZF2
103 1.299601e-97 2.009110 0.568 0.061 2.878097e-93 5 TNFRSF4
104 7.681643e-97 1.321279 0.420 0.023 1.701177e-92 5 RTKN2
105 1.061341e-80 1.338158 0.784 0.166 2.350447e-76 5 CTLA4
106 7.039355e-76 1.152189 0.483 0.055 1.558936e-71 5 TBC1D4
107 3.871462e-69 1.433235 0.705 0.166 8.573739e-65 5 BATF
108 1.378822e-66 1.115265 0.301 0.018 3.053540e-62 5 LAYN
109 7.964150e-64 1.091478 0.472 0.064 1.763741e-59 5 LINC01943
110 6.875167e-59 1.426549 0.557 0.108 1.522574e-54 5 TNFRSF18
111 1.047703e-56 1.465888 0.858 0.352 2.320244e-52 5 LTB
112 2.520268e-55 1.131236 0.767 0.241 5.581385e-51 5 TIGIT
113 5.417568e-55 1.169037 0.983 0.670 1.199775e-50 5 IL32
114 6.603943e-51 1.072359 0.932 0.508 1.462509e-46 5 SAT1
115 1.056314e-50 1.097797 0.767 0.265 2.339312e-46 5 UGP2
116 2.262464e-43 1.089484 0.739 0.284 5.010453e-39 5 COX5A
117 8.992932e-42 1.117256 0.676 0.241 1.991575e-37 5 SPATS2L
118 2.443286e-41 1.145624 0.256 0.027 5.410902e-37 5 SOX4
119 5.386094e-14 1.220360 0.432 0.211 1.192804e-09 5 IFI27
120 8.713195e-181 2.092355 0.752 0.027 1.929624e-176 6 FCER1G
121 7.767781e-151 2.045144 0.686 0.030 1.720253e-146 6 KLRC1
122 5.396192e-145 1.828375 0.743 0.041 1.195041e-140 6 TYROBP
123 2.965899e-137 3.273955 0.924 0.097 6.568281e-133 6 GNLY
124 5.239694e-130 1.621100 0.695 0.039 1.160383e-125 6 TRDC
125 1.124065e-96 1.978970 0.848 0.119 2.489354e-92 6 KLRD1
126 1.320810e-84 1.558874 0.629 0.061 2.925066e-80 6 XCL1
127 1.173589e-73 1.568917 0.676 0.089 2.599030e-69 6 XCL2
128 6.514180e-66 2.242573 0.781 0.160 1.442630e-61 6 AREG
129 3.189367e-63 1.882625 0.714 0.122 7.063171e-59 6 GZMB
130 1.330667e-60 1.504170 0.733 0.138 2.946895e-56 6 CTSW
131 6.356591e-59 1.238446 0.524 0.065 1.407731e-54 6 IFITM3
132 6.350508e-58 1.318599 0.543 0.070 1.406383e-53 6 HOPX
133 2.350804e-45 1.121467 0.581 0.103 5.206090e-41 6 TXK
134 2.361141e-41 1.204923 0.771 0.232 5.228984e-37 6 CD63
135 3.254807e-39 1.433198 0.857 0.355 7.208096e-35 6 NKG7
136 5.462333e-31 1.131880 0.686 0.224 1.209688e-26 6 IL2RB
137 1.807304e-30 1.211762 0.514 0.119 4.002456e-26 6 CLIC3
138 3.089079e-24 1.262044 0.590 0.192 6.841075e-20 6 LGALS1
139 1.514107e-11 1.184581 0.267 0.079 3.353140e-07 6 CCL3
140 5.284171e-41 3.224406 0.759 0.250 1.170232e-36 7 PLCG2
141 6.596360e-38 1.404242 0.977 0.699 1.460830e-33 7 IGKC
142 2.009245e-17 0.892825 0.851 0.624 4.449673e-13 7 RPS26
143 7.916210e-16 0.553736 1.000 0.990 1.753124e-11 7 RPS27
144 2.607058e-14 0.667050 0.920 0.692 5.773591e-10 7 CD52
145 8.036477e-14 0.692388 0.425 0.150 1.779758e-09 7 IGLC2
146 1.562652e-10 0.704667 0.264 0.077 3.460649e-06 7 HSPA1B
147 3.403016e-09 0.770959 0.655 0.460 7.536320e-05 7 ITGB1
148 7.258595e-09 0.846541 0.368 0.159 1.607489e-04 7 LINC01871
149 1.478003e-07 0.656315 0.253 0.092 3.273186e-03 7 ST8SIA4
150 1.698407e-07 0.754366 0.276 0.109 3.761293e-03 7 THEMIS
151 2.383580e-07 0.584989 0.724 0.554 5.278677e-03 7 S100A4
152 1.095542e-06 0.561128 0.690 0.608 2.426188e-02 7 AAK1
153 3.134849e-06 0.685325 0.299 0.138 6.942438e-02 7 FAM118A
154 1.445564e-05 0.610202 0.471 0.322 3.201345e-01 7 MACF1
155 2.957615e-05 0.534259 0.414 0.256 6.549933e-01 7 CD63
156 4.185983e-05 0.597558 0.368 0.210 9.270278e-01 7 ITGB2
157 7.250040e-05 0.556541 0.299 0.160 1.000000e+00 7 KIAA1109
158 1.473287e-04 0.585402 0.276 0.150 1.000000e+00 7 PPP1R18
159 1.286750e-03 0.531888 0.299 0.184 1.000000e+00 7 GTF2I
160 2.237921e-58 1.783138 0.783 0.096 4.956100e-54 8 CXCL13
161 1.310956e-53 1.740598 0.850 0.133 2.903244e-49 8 GZMB
162 4.653728e-47 0.875808 0.417 0.030 1.030615e-42 8 ITGA2
163 4.693506e-46 1.203169 0.617 0.074 1.039424e-41 8 HAVCR2
164 2.846019e-36 0.993085 0.550 0.073 6.302794e-32 8 CARS
165 5.812481e-33 1.098408 0.683 0.123 1.287232e-28 8 HLA-DQA1
166 3.493756e-27 1.230512 0.800 0.231 7.737271e-23 8 HLA-DRA
167 2.230911e-26 0.936829 0.700 0.151 4.940576e-22 8 LINC01871
168 4.778326e-24 1.124005 0.917 0.312 1.058208e-19 8 HLA-DRB1
169 1.571020e-23 1.053152 0.583 0.127 3.479181e-19 8 PTMS
170 3.788818e-23 1.072953 0.750 0.208 8.390717e-19 8 CTLA4
171 5.595790e-23 0.974294 0.450 0.078 1.239244e-18 8 ENTPD1
172 5.279518e-21 1.015886 0.317 0.043 1.169202e-16 8 LINC02446
173 9.103088e-20 0.919396 0.383 0.065 2.015970e-15 8 SPRY1
174 3.678210e-18 0.910198 0.883 0.387 8.145764e-14 8 ALOX5AP
175 7.062779e-16 0.952292 1.000 0.655 1.564123e-11 8 CCL5
176 3.525239e-15 1.069108 0.750 0.319 7.806995e-11 8 RBPJ
177 3.592725e-14 1.322262 0.617 0.220 7.956448e-10 8 IFI27
178 2.437596e-12 1.392320 0.350 0.081 5.398301e-08 8 CCL3
179 2.858023e-11 0.947422 0.500 0.172 6.329378e-07 8 KLRB1
180 4.466570e-260 2.235401 0.829 0.005 9.891667e-256 9 ASPM
181 5.290189e-236 2.477301 0.976 0.015 1.171565e-231 9 MKI67
182 5.114396e-210 2.296445 0.756 0.007 1.132634e-205 9 TOP2A
183 1.668751e-205 1.354341 0.585 0.002 3.695617e-201 9 DLGAP5
184 3.077361e-156 1.625392 0.732 0.014 6.815124e-152 9 TPX2
185 4.450686e-140 1.468862 0.537 0.006 9.856488e-136 9 TYMS
186 6.142486e-129 1.341821 0.561 0.009 1.360315e-124 9 PCLAF
187 1.553878e-107 2.464197 0.902 0.050 3.441218e-103 9 STMN1
188 3.207136e-106 1.415162 0.537 0.012 7.102522e-102 9 CENPE
189 4.618191e-98 1.879310 0.756 0.035 1.022745e-93 9 NUSAP1
190 5.989234e-82 2.409591 0.805 0.054 1.326376e-77 9 CENPF
191 8.567855e-69 1.379622 0.610 0.033 1.897437e-64 9 CKS1B
192 4.935251e-65 1.369396 0.707 0.049 1.092961e-60 9 SMC2
193 1.365738e-56 2.074883 0.902 0.116 3.024564e-52 9 TUBB
194 1.496871e-41 2.014897 0.951 0.201 3.314971e-37 9 TUBA1B
195 3.866533e-37 1.403323 0.854 0.145 8.562824e-33 9 SMC4
196 1.024617e-26 1.801311 0.951 0.383 2.269116e-22 9 HMGB2
197 1.484176e-23 1.472982 0.902 0.328 3.286856e-19 9 H2AFZ
198 4.063593e-21 1.514462 0.927 0.472 8.999234e-17 9 HMGN2
199 1.090591e-17 1.853865 0.902 0.414 2.415224e-13 9 HIST1H4C

Pathways



DNA_REPAIR

-5 0 5 10 -10 -5 0 5 10 UMAP-1 UMAP-2 -1 0 1 2 DNA_REPAIR Score Pearson CLSTN1 YARS ADAM15 ARF1 CMTM8 MANF AIMP1 HMGB2 VEGFA LAMB1 PTDSS1 CADM1 ITGB1 PLAU HSP90B1 GPI RPS19 DUSP18 WISP3 Ligand activity Prioritized Ovarian.cancer.cell ligands TEST_ASN TEST_ION TEST_RAP CLSTN1 YARS ADAM15 ARF1 CMTM8 MANF AIMP1 HMGB2 VEGFA LAMB1 PTDSS1 CADM1 ITGB1 PLAU HSP90B1 GPI RPS19 DUSP18 WISP3 Sample COX17 POLA1 HPRT1 SDCBP POLD4 PRIM1 VPS37B RAD51 TP53 NME1 TYMS PCNA POLR2E ERCC1 MRPL40 CCNO CLSTN1 YARS ADAM15 ARF1 CMTM8 MANF AIMP1 HMGB2 VEGFA LAMB1 PTDSS1 CADM1 ITGB1 PLAU HSP90B1 GPI RPS19 DUSP18 WISP3 DNA_REPAIR genes in Ovarian.cancer.cell POLR2E PCNA ERCC1 POLD4 NME1 VPS37B PRIM1 RAD51 SDCBP TP53 TYMS POLA1 HPRT1 MRPL40 COX17 CCNO TEST_ASN TEST_ION TEST_RAP Sample 0.01 0.02 0.03 0.04 0.05 Pearson correlation coefficient (target gene prediction ability) 1 2 3 4 Expression (averaged over single cells) 0.000 0.005 Regulatory potential 0.00 0.25 0.50 0.75 1.00 Scaled expression (averaged over single cells)
INTERFERON_GAMMA_RESPONSE
INFLAMMATORY_RESPONSE

Subtypes



HRD-Ovarian-cancer-cell
-5 0 5 10 -10 -5 0 5 10 UMAP-1 UMAP-2 -1 0 1 2 HRD Score 0 50 100 150 200 -1 0 1 2 3 Score Cells HRD Score -1 0 1 2 3 PATIENT1 PATIENT2 HRD Score Sample Summary -1 0 1 2 3 TEST_ION TEST_ASN TEST_RAP HRD Score Batch Summary
Exhausted-T-cell
-3 0 3 6 -5.0 -2.5 0.0 2.5 5.0 UMAP-1 UMAP-2 -1 0 1 2 3 Exhausted Score 0 200 400 600 -1 0 1 2 3 Score Cells Exhausted Score -1 0 1 2 3 PATIENT1 PATIENT2 Exhausted Score Sample Summary -1 0 1 2 3 TEST_IOP TEST_RAP Exhausted Score Batch Summary